Gräber H G, Conrads G, Wilharm J, Lampert F
Clinic of Conservative & Preventive Dentistry and Periodontology, Technical University, Aachen, Germany.
J Periodontol. 1999 Dec;70(12):1511-22. doi: 10.1902/jop.1999.70.12.1511.
Following the surgical treatment of adult periodontitis, the epithelial regeneration of the periodontal attachment is non-physiological and thus unsatisfactory, if membranes or artificial bone material are not used. Re-epithelialization is based on the proliferation, migration, and differentiation of basal epithelial cells which are in contact with a wound matrix and whose molecular makeup differs from the extracellular matrix of intact regions. Interactions between basal epithelial cells and the extracellular matrix are mediated by special receptors on the cell surface which are known as integrins and belong to the family of cellular adhesion molecules (CAM). Various studies indicate that integrin-mediated interaction plays a decisive role in regulating the proliferation, migration, and differentiation of the epithelial cells. This review provides an overview of the in vivo and in vitro expression of integrins by epithelial cells and the interaction between integrins and extracellular matrix (ECM) in the case of a stationary epithelium and during wound healing. The regulation of these cell-cell and cell-matrix interactions may represent a method for inhibiting non-physiological epithelial regeneration on the molecular level.
在成人牙周炎的外科治疗后，如果不使用膜或人工骨材料，牙周附着的上皮再生是非生理性的，因此效果不理想。再上皮化基于与伤口基质接触的基底上皮细胞的增殖、迁移和分化，其分子组成不同于完整区域的细胞外基质。基底上皮细胞与细胞外基质之间的相互作用由细胞表面的特殊受体介导，这些受体称为整合素，属于细胞粘附分子（CAM）家族。各种研究表明，整合素介导的相互作用在调节上皮细胞的增殖、迁移和分化中起决定性作用。本综述概述了上皮细胞整合素在体内和体外的表达，以及在静止上皮和伤口愈合情况下整合素与细胞外基质（ECM）之间的相互作用。这些细胞-细胞和细胞-基质相互作用的调节可能代表了一种在分子水平上抑制非生理性上皮再生的方法。
