Liu Hui, Yang Heng-lin, Zhang Jun, Li Chun-Fu, Nie Ren-hua, Wang Heng-ye
Yunnan Instiute of Parasitic Diseases, Yunnan Center of Malaria Research, Institute of Vector and Pathogen Biology of Dali University, Simao 665000, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2011 Aug;29(4):296-8.
To observe the therapeutic efficacy of compound dihydroartemisinin-piperaquine for treatment of uncomplicated falciparum malaria in Myanmar.
From 2007 to 2008, patients aged 6 to 60 years with uncomplicated P. falciparum infection and parasite density 500 to 200 000 parasites/microl were enrolled following an informed consent. A three-day course of total 8 tablets compound dihydroartemisinin-piperaquine was administered to an adult (each tablet containing 40 mg of dihydroartemisinin and 320 mg of piperaquine phosphate), dosage for children was based on ages (details in the treatment regimen) . The indices including fever subsiding time, parasite clearance time, asexual parasite clearance time and adverse clinical responses were observed and collected on days 7, 14, 21, and 28 after treatment.
A total of 134 patients completed the treatment. The mean fever subsiding time and mean asexual parasite clearance time were (25.5 +/- 2.8) h and (39.5 +/- 7.8) h respectively. Asexual parasite clearance rate was 100% on day 7. Four cases recrudesced on day 28 and 16 cases had slight adverse clinical responses such as uncomfortable gastrointestinal tract, headache, nausea, vomit and diarrhea, which disappeared as soon as drug withdrawal.
The compound dihydroartemisinin/piperaquine shows a sound efficacy in treating uncomplicated falciparum malaria
观察复方双氢青蒿素哌喹治疗缅甸无并发症恶性疟的疗效。
2007年至2008年，纳入年龄在6至60岁、无并发症恶性疟原虫感染且寄生虫密度为500至200 000个/微升的患者，患者均签署知情同意书。给予成人一个疗程为期三天共8片的复方双氢青蒿素哌喹（每片含40毫克双氢青蒿素和320毫克磷酸哌喹），儿童剂量根据年龄而定（治疗方案中有详细说明）。在治疗后第7、14、21和28天观察并收集包括退热时间、寄生虫清除时间、无性寄生虫清除时间及临床不良反应等指标。
共有134例患者完成治疗。平均退热时间和平均无性寄生虫清除时间分别为(25.5±2.8)小时和(39.5±7.8)小时。第7天无性寄生虫清除率为100%。28天时有4例复发，16例出现轻微临床不良反应，如胃肠道不适、头痛、恶心、呕吐和腹泻，停药后症状即消失。
复方双氢青蒿素/哌喹治疗无并发症恶性疟疗效良好
