Perez Gutierrez Rosa Martha, Garcia Baez Efren
Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas IPN, Av Instituto Politecnico Nacional S/N, Zacatenco, CP 07708, Mexico DF.
J Asian Nat Prod Res. 2011 Oct;13(10):934-41. doi: 10.1080/10286020.2011.601744.
Three new isopimarane diterpenes 7β-hydroxy-19α-methylmalonyloxy-isopimara-8(14),15-diene (1), 7β-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid (2), and 7β-hydroxy-14-oxo-19α-methylmalonyloxy-isopimara-9(11),15-diene (3) in addition to the known compounds isopimaric acid (4), 7oxo-13-epi-pimara-14,15-dien-18oic acid (5), 7oxo-13-epi-pimara-8,15-dien-18oic acid (6), and 6β-hydroxyisopimaric acid (7) were isolated from the hexane extract of Rhizoclonium hieroglyphicum. The structures of compounds 1-7 were established by 1D and 2D NMR techniques. The isolated diterpenoids were screened for antimicrobial activity against gram-positive and gram-negative bacteria and yeast strains.
除了已知化合物异海松酸（4）、7-氧代-13-表-海松-14,15-二烯-18-酸（5）、7-氧代-13-表-海松-8,15-二烯-18-酸（6）和6β-羟基异海松酸（7）外，还从象形根枝藻的己烷提取物中分离出三种新的异海松烷二萜7β-羟基-19α-甲基丙二酰氧基-异海松-8(14),15-二烯（1）、7β-羟基-14-氧代-异海松-8(9),15-二烯-19-酸（2）和7β-羟基-14-氧代-19α-甲基丙二酰氧基-异海松-9(11),15-二烯（3）。通过一维和二维核磁共振技术确定了化合物1-7的结构。对分离得到的二萜类化合物进行了针对革兰氏阳性菌、革兰氏阴性菌和酵母菌株的抗菌活性筛选。
