来自具有抗菌活性的淡水绿藻象形根枝藻的二萜类化合物。
Diterpenoids from the freshwater green algae Rhizoclonium hieroglyphicum with antibacterial activity.
作者信息
Perez Gutierrez Rosa Martha, Garcia Baez Efren
机构信息
Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingeniería Química e Industrias Extractivas IPN, Av Instituto Politecnico Nacional S/N, Zacatenco, CP 07708, Mexico DF.
出版信息
J Asian Nat Prod Res. 2011 Oct;13(10):934-41. doi: 10.1080/10286020.2011.601744.
Three new isopimarane diterpenes 7β-hydroxy-19α-methylmalonyloxy-isopimara-8(14),15-diene (1), 7β-hydroxy-14-oxo-isopimara-8(9),15-dien-19oic acid (2), and 7β-hydroxy-14-oxo-19α-methylmalonyloxy-isopimara-9(11),15-diene (3) in addition to the known compounds isopimaric acid (4), 7oxo-13-epi-pimara-14,15-dien-18oic acid (5), 7oxo-13-epi-pimara-8,15-dien-18oic acid (6), and 6β-hydroxyisopimaric acid (7) were isolated from the hexane extract of Rhizoclonium hieroglyphicum. The structures of compounds 1-7 were established by 1D and 2D NMR techniques. The isolated diterpenoids were screened for antimicrobial activity against gram-positive and gram-negative bacteria and yeast strains.
除了已知化合物异海松酸（4）、7-氧代-13-表-海松-14,15-二烯-18-酸（5）、7-氧代-13-表-海松-8,15-二烯-18-酸（6）和6β-羟基异海松酸（7）外，还从象形根枝藻的己烷提取物中分离出三种新的异海松烷二萜7β-羟基-19α-甲基丙二酰氧基-异海松-8(14),15-二烯（1）、7β-羟基-14-氧代-异海松-8(9),15-二烯-19-酸（2）和7β-羟基-14-氧代-19α-甲基丙二酰氧基-异海松-9(11),15-二烯（3）。通过一维和二维核磁共振技术确定了化合物1-7的结构。对分离得到的二萜类化合物进行了针对革兰氏阳性菌、革兰氏阴性菌和酵母菌株的抗菌活性筛选。
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