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来自海洋红藻玛丽安劳伦氏藻的二萜、倍半萜和一种C15产乙酸素。

Diterpenes, sesquiterpenes, and a C15-acetogenin from the marine red alga Laurencia mariannensis.

作者信息

Ji Nai-Yun, Li Xiao-Ming, Li Ke, Ding Lan-Ping, Gloer James B, Wang Bin-Gui

机构信息

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, PR China.

出版信息

J Nat Prod. 2007 Dec;70(12):1901-5. doi: 10.1021/np070378b. Epub 2007 Dec 13.

DOI:10.1021/np070378b
PMID:18076141
Abstract

In addition to 10 known compounds (7- 16), one new brominated diterpene, 10-hydroxykahukuene B (1), two new sesquiterpenes, 9-deoxyelatol (2) and isodactyloxene A (3), one new brominated C 15-acetogenin, laurenmariallene (4), and two new naturally occurring halogenated sesquiterpenes (5 and 6) that were previously obtained as intermediates in a biomimetic synthetic study of rhodolaureol and rhodolauradiol have been isolated and identified from the organic extract of the marine red alga Laurencia mariannensis. The structures of these compounds were established by spectroscopic methods. The antibacterial and antifungal activities of new compounds 1-4 were evaluated.

摘要

除了10种已知化合物(7 - 16)外,从海洋红藻劳伦氏藻(Laurencia mariannensis)的有机提取物中分离并鉴定出一种新的溴化二萜,10 - 羟基卡胡库烯B(1),两种新的倍半萜,9 - 脱氧埃拉托醇(2)和异指烯A(3),一种新的溴化C15 - 产乙酸素,劳伦玛丽烯(4),以及两种新的天然卤化倍半萜(5和6),这两种化合物先前是在红藻醇和红藻二醇的仿生合成研究中作为中间体获得的。这些化合物的结构通过光谱方法确定。对新化合物1 - 4的抗菌和抗真菌活性进行了评估。

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