Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA.
Epilepsia. 2011 Oct;52(10):e130-4. doi: 10.1111/j.1528-1167.2011.03263.x. Epub 2011 Sep 13.
Previous studies of epileptic spasms reported that ictal events were associated with high-frequency oscillations (HFOs) or delta waves involving widespread regions. We determined whether ictal HFOs at 80-200 Hz were coupled with a phase of slow-wave, whether ictal slow-waves were diffusely or locally synchronous signals, and whether the mode of coupling between HFOs and slow-wave phases differed between ictal and interictal states. We studied 11 children who underwent extraoperative electrocorticography (ECoG) recording. The phases and amplitudes of slow-waves were measured at the peak of ictal and interictal HFOs in the seizure-onset sites. Ictal HFOs were locked tightly to the phase of slow-wave at ≤1 Hz. Ictal slow-waves propagated from the seizure-onset site to other regions. In contrast, interictal HFOs in the seizure-onset site were loosely locked to the phase of slow-wave at ≤1 Hz but tightly to that of ≥3-Hz. Ictal slow-waves coupled with HFOs can be explained as near-field and locally synchronized potentials generated by the neocortex rather than far-field potentials generated by subcortical structures. Ictal slow-waves in epileptic spasms may be generated by a mechanism different from what generates interictal HFOs-slow-wave complexes.
先前关于癫痫痉挛的研究报告指出，发作事件与涉及广泛区域的高频振荡（HFOs）或δ波有关。我们确定了 80-200Hz 的发作 HFO 是否与慢波相位耦合，发作慢波是否为弥散或局部同步信号，以及 HFO 与慢波相位之间的耦合模式在发作期和发作间期是否存在差异。我们研究了 11 名接受手术外皮层电图（ECoG）记录的儿童。在发作起始部位的发作和发作间期 HFO 峰值处测量慢波的相位和幅度。发作 HFO 在 ≤1Hz 时与慢波相位紧密锁定。发作性慢波从发作起始部位传播到其他区域。相比之下，在发作起始部位的发作间期 HFO 在 ≤1Hz 时与慢波相位松散锁定，但在 ≥3Hz 时紧密锁定。发作 HFO 与慢波的耦合可以解释为由新皮层产生的近场和局部同步电位，而不是由皮质下结构产生的远场电位。癫痫痉挛中的发作性慢波可能是由与产生发作间期 HFO-慢波复合体不同的机制产生的。
