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体重指数是单纯非体外循环冠状动脉血运重建的危险因素吗?

Is body mass index a risk factor for isolated off-pump coronary revascularization?

作者信息

Bhamidipati Castigliano M, Seymour Keri A, Cohen Noah, Rolland Roberta, Dilip Karikehalli A, Lutz Charles J

机构信息

Department of Surgery, Division of Cardiothoracic Surgery, State University of New York Upstate Medical University School of Medicine, Syracuse, New York 13210, USA.

出版信息

J Card Surg. 2011 Nov;26(6):565-71. doi: 10.1111/j.1540-8191.2011.01312.x. Epub 2011 Oct 5.

Abstract

OBJECTIVE

The influence of body mass index (BMI) as a risk factor for isolated off-pump coronary artery bypass (OPCAB) surgery is unknown. We postulated that BMI ≥ 30 kg/m(2) would adversely affect outcomes following OPCAB at our institution.

METHODS

From 2002 to 2009, we selected 742 patients (primary, N = 709 [95.6%], re-operative, N = 33 [4.45%]) who underwent isolated OPCAB for analysis. Patients were stratified into groups by BMI: non-obese (BMI < 30 kg/m(2) ) and obese (BMI ≥ 30 kg/m(2)). Preoperative risk, operative characteristics, and postoperative outcomes were analyzed. Risk-adjusted models evaluated the occurrence of any complication and mortality.

RESULTS

Overall crude mortality was 1.5% (11/742). When compared to non-obese (26.12 ± 2.72 kg/m(2)) recipients, the obese (35.81 ± 5.69 kg/m(2)) comprised younger patients (62.46 ± 9.96 years, p < 0.001). Number of diseased vessels, Left ventricular ejection fraction, and baseline renal function was equivalent across groups. Diabetes (53.24%) and hypertension (90.59%) were more prevalent among obese patients (p < 0.001, respectively). Internal mammary artery utilization (p = 0.47), endoscopic vein harvest (p = 0.74), and intra-aortic balloon pump use (p = 0.58) were similar between groups. Interestingly, postoperative blood product requirement was lower in obese versus non-obese recipients (47.35% vs. 56.72%, p < 0.01). Furthermore, intensive care unit stay (p = 0.93), mortality (p = 0.56), and discharge to home (p = 0.09) remained equivalent between groups. Importantly, multivariable logistic regression did not identify BMI ≥ 30 kg/m(2) as an independent predictor of any complication (p = 0.21) or mortality (p = 0.74).

CONCLUSIONS

Obesity does not influence operative characteristics or effect outcomes after OPCAB. BMI ≥ 30 kg/m(2) should not be considered a prohibitive risk factor in isolated off-pump coronary revascularization.

摘要

目的

体重指数(BMI)作为非体外循环冠状动脉搭桥术(OPCAB)的一个危险因素,其影响尚不清楚。我们推测,BMI≥30kg/m²会对我院接受OPCAB手术的患者的预后产生不利影响。

方法

从2002年至2009年,我们选取了742例行单纯OPCAB手术的患者(初次手术,N = 709例[95.6%],再次手术,N = 33例[4.45%])进行分析。患者按BMI分层:非肥胖组(BMI < 30kg/m²)和肥胖组(BMI≥30kg/m²)。分析术前风险、手术特征和术后结果。风险调整模型评估任何并发症的发生情况和死亡率。

结果

总体粗死亡率为1.5%(11/742)。与非肥胖患者(26.12±2.72kg/m²)相比,肥胖患者(35.81±5.69kg/m²)年龄较轻(62.46±9.96岁,p < 0.001)。各组间病变血管数量、左心室射血分数和基线肾功能相当。糖尿病(53.24%)和高血压(90.59%)在肥胖患者中更为常见(p分别< 0.001)。两组间乳内动脉使用率(p = 0.47)、内镜下取静脉率(p = 0.74)和主动脉内球囊泵使用率(p = 0.58)相似。有趣的是,肥胖患者术后血液制品需求量低于非肥胖患者(47.35%对56.72%,p < 0.01)。此外,两组间重症监护病房住院时间(p = 0.93)、死亡率(p = 0.56)和出院回家情况(p = 0.09)相当。重要的是,多变量逻辑回归未将BMI≥30kg/m²确定为任何并发症(p = 0.21)或死亡率(p = 0.74)的独立预测因素。

结论

肥胖不影响OPCAB手术后的手术特征或预后。BMI≥30kg/m²不应被视为单纯非体外循环冠状动脉血运重建的禁忌危险因素。

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