Department of Endocrinology, Hvidovre Hospital, Copenhagen, Denmark.
Endocr Res. 2011;36(4):135-41. doi: 10.3109/07435800.2011.554937.
We tested the hypothesis that 25-hydroxyvitamin D3 (25OHD) changes during acute inflammation in humans.
Patients with first episode of acute pancreatitis were included. Blood samples were acquired on admission and on days 1, 2, and 14.
In total, 73 patients (35 males, median age 59) entered the study. On admission, the distribution of 25-OHD levels was as follows: severely deficient (<13 nmol/L) 23%; deficient (13-25 nmol/L) 20%; insufficient (26-50 nmol/L) 40%; and normal (<50 nmol/L) 17%. There was a significant fall and linear trend in 25OHD, albumin, and hemoglobin from day 0 to day 2. From day 0 to day 2 the drop in 25OHD was 3.1 nmol/L (95% CI 0.59-5.63). The changes from day 0 to day 2 in 25OHD were associated with changes in C-reactive protein (p = 0.02) but not with leukocyte or monocyte count.
The 25OHD levels dropped during the first 2 days of acute pancreatitis beyond what was expected based on 25OHD half-life. This study supports our hypothesis that an acute inflammatory condition utilizes 25OHD, but other mechanisms could interfere.
我们检验了人类急性炎症期间 25-羟维生素 D3（25OHD）变化的假说。
纳入首次发作急性胰腺炎的患者。入院时及第 1、2 和 14 天采集血样。
共有 73 例患者（35 名男性，中位年龄 59 岁）入组研究。入院时，25-OHD 水平的分布如下：严重缺乏（<13nmol/L）23%；缺乏（13-25nmol/L）20%；不足（26-50nmol/L）40%；正常（<50nmol/L）17%。25OHD、白蛋白和血红蛋白从第 0 天到第 2 天显著下降并呈线性趋势。与第 0 天相比，第 2 天 25OHD 下降 3.1nmol/L（95%CI 0.59-5.63）。第 0 天到第 2 天 25OHD 的变化与 C 反应蛋白的变化相关（p=0.02），但与白细胞或单核细胞计数无关。
急性胰腺炎的最初 2 天内，25OHD 水平下降超出了根据 25OHD 半衰期所预计的水平。本研究支持我们的假说，即急性炎症状态利用 25OHD，但其他机制也可能会产生干扰。
