Department of Radiotherapy, CSM Medical University, Lucknow, Uttar Pradesh, India.
World J Surg Oncol. 2011 Oct 5;9:118. doi: 10.1186/1477-7819-9-118.
Malignant tumors of the nasal cavity are rare. We report the case of a 48 years old man who consulted us with a 2-year history of progressive nasal obstruction, occasional epistaxis, facial pain, and watering of the eyes. A diagnosis of olfactory neuroblastoma was established by histopathology and confirmed by immunohistochemistry. On staging, the mass was classified as a Kadish stage C tumor with extensive involvement of the nasal cavities, nasopharynx, paranasal sinuses and orbit. Endoscopic excision of the mass was done. Traditionally the mainstay of treatment in such locally advanced patients is craniofacial resection followed by adjuvant radiotherapy. Our patient was treated with limited surgery and chemoradiation. Patient is free of recurrence at a follow-up of 5 years. This case report demonstrates the potential efficacy of planned combined modality therapy, including limited surgery and early chemoradiation in the control of locally advanced olfactory neuroblastoma.
鼻腔恶性肿瘤较为罕见。我们报告了 1 例 48 岁男性患者，其病史为渐进性鼻塞 2 年，偶有鼻出血、面部疼痛和流泪。通过组织病理学和免疫组织化学检查确立嗅神经母细胞瘤的诊断。分期时，肿块被归类为 Kadish 期 C 肿瘤，鼻腔、鼻咽、副鼻窦和眼眶广泛受累。对肿块进行了内镜切除。传统上，对于此类局部晚期患者，主要治疗方法是颅面切除术，然后辅助放疗。我们的患者接受了有限的手术和放化疗。患者在随访 5 年后无复发。本病例报告证明了计划的综合治疗模式（包括有限手术和早期放化疗）在控制局部晚期嗅神经母细胞瘤方面的潜在疗效。
