Ul'ianinskiĭ L S, Ivanov V T, Mikhaleva I I, Sudakov K V
Kosm Biol Aviakosm Med. 1990 May-Jun;24(3):23-8.
In acute and chronic animal (rabbits, rats) experiments it has been shown that delta-sleep producing peptide (DSPP) exerts a noticeable effect on the cardiac function and regulation. DSPP at a dose of 60 nm/kg can prolong the effects of vagus and inhibit those of sympathetic nerves on the cardiac function and, consequently, can influence the function of choline- and adrenergic transmitters. DSPP blocks pressor vascular reactions in response to direct electrical stimulation of ventromedian hypothalamus and thus increases the survival of animals exposed to an acute emotional stress. DSPP normalizes the electrical stability of the heart and produces an antiarrhythmic effect on ventricular ectopic beats that occur in response to emotional stresses. In view of this, DSPP can be recommended for clinical trials as a drug preventing cardiac arrhythmias in stressful situations.
在急性和慢性动物（兔子、大鼠）实验中已表明，δ-睡眠诱导肽（DSPP）对心脏功能和调节具有显著作用。剂量为60纳米/千克的DSPP可延长迷走神经的作用并抑制交感神经对心脏功能的作用，因此可影响胆碱能和肾上腺素能递质的功能。DSPP可阻断因直接电刺激下丘脑腹内侧核而引起的升压血管反应，从而提高遭受急性情绪应激动物的存活率。DSPP可使心脏的电稳定性正常化，并对因情绪应激而出现的室性早搏产生抗心律失常作用。鉴于此，DSPP可作为一种在应激情况下预防心律失常的药物推荐用于临床试验。
