Reuter-Rice Karin, Duthie Susan, Hamrick Justin
Division of Pediatric Critical Care Medicine, Rady Children's Hospital, San Diego, CA, USA.
Pediatr Emerg Care. 2011 Oct;27(10):957-8. doi: 10.1097/PEC.0b013e3182309eac.
Neurogenic pulmonary edema (NPE) can result from various central nervous system disorders such as brain malignancies, traumatic brain injuries, infections, and seizures. Although the pathogenesis is not completely understood, NPE creates an increase in pulmonary interstitial and alveolar fluid. In adults, it has been reported with prolonged seizure activity. In pediatric patients, pulmonary edema has rarely been reported after status epilepticus, and respiratory compromise is most often due to anticonvulsant-related respiratory depression. Treatment for NPE is largely supportive. If unrecognized, it can lead to hypoxia and respiratory arrest. We report a case of status epilepticus-related pulmonary edema in a female toddler, the youngest patient to be reported in the literature.
神经源性肺水肿(NPE)可由多种中枢神经系统疾病引起,如脑恶性肿瘤、创伤性脑损伤、感染和癫痫发作。尽管其发病机制尚未完全明确,但NPE会导致肺间质和肺泡液增多。在成人中,已有报道称其与癫痫持续发作有关。在儿科患者中,癫痫持续状态后很少有肺水肿的报道,呼吸功能不全最常见的原因是抗惊厥药物相关的呼吸抑制。NPE的治疗主要是支持性的。如果未被识别,它可能导致缺氧和呼吸骤停。我们报告了一例女性幼儿癫痫持续状态相关肺水肿的病例,这是文献报道中最年幼的患者。