Grossniklaus H E, Zimmerman L E, Kachmer M L
Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA.
Ophthalmology. 1990 Jun;97(6):763-8. doi: 10.1016/s0161-6420(90)32522-8.
An 80-year-old man was evaluated for an epibulbar tumor on a phthisical eye. The initial biopsy diagnosis of the epibulbar tumor was poorly differentiated neoplasm. Exenteration of the phthisical eye and orbital contents showed an extensive pleomorphic adenocarcinoma of the nonpigmented epithelium of the ciliary body with extraocular extension. There was evidence of hyaluronic acid secretion and immunohistochemical staining was strong for vimentin, focal for epithelial membrane antigen and S-100 protein, and weak for neuron-specific-enolase. Electron microscopy demonstrated desmosomes between tumor cells, areas of thick, multilaminar basement membrane production surrounding individual tumor cells, and occasional intracytoplasmic intermediate filaments.
一名80岁男性因一只痨眼上的眼球表面肿瘤接受评估。眼球表面肿瘤的初始活检诊断为低分化肿瘤。痨眼及眶内容物摘除术显示为睫状体无色素上皮的广泛多形性腺癌，并伴有眼外扩展。有透明质酸分泌的证据，免疫组化染色显示波形蛋白呈强阳性，上皮膜抗原和S-100蛋白呈局灶性阳性，神经元特异性烯醇化酶呈弱阳性。电子显微镜显示肿瘤细胞之间有桥粒，单个肿瘤细胞周围有增厚的多层基底膜形成区域，偶尔可见胞质内中间丝。
