睫状体上皮多形性腺癌：1例罕见病例的临床病理、免疫组化、超微结构、DNA倍体及比较基因组杂交分析
Pleomorphic adenocarcinoma of the ciliary epithelium: a clinicopathological, immunohistochemical, ultrastructural, DNA-ploidy and comparative genomic hybridization analysis of an unusual case.
作者信息
Nicolò M, Nicolò G, Zingirian M
机构信息
Department of Neurological and Visual Sciences, University of Genova, Italy.
出版信息
Eur J Ophthalmol. 2002 Jul-Aug;12(4):319-23. doi: 10.1177/112067210201200412.
PURPOSE
To describe detailed phenotypic and genotypic analysis of a pleomorphic adenocarcinoma of the ciliary epithelium (CE).
CASE REPORT
An 86-year-old white woman developed an enlarging mass protruding from her previously eviscerated left eye 2 months postoperatively. Based on light and ultrastructural microscopy, the final diagnosis was a pleomorphic adenocarcinoma of the ciliary epithelium (CE).
DISCUSSION
Cell proliferation indices confirmed the unusually rapid growth rate of this tumor; the peridiploid DNA content might explain the relatively low incidence of distant metastases. An imbalance of the chromosome 6 was also found by Comparative Genomic Hybridization (CGH).
目的
描述睫状体上皮多形性腺癌的详细表型和基因型分析。
病例报告
一名86岁白人女性在左眼眼球摘除术后2个月，出现一个从手术眼突出且不断增大的肿块。基于光镜和超微结构显微镜检查，最终诊断为睫状体上皮多形性腺癌。
讨论
细胞增殖指数证实了该肿瘤异常快速的生长速度；亚二倍体DNA含量可能解释了远处转移相对较低的发生率。通过比较基因组杂交（CGH）还发现了6号染色体的不平衡。
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