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食管鳞癌细胞质叉头框 M1（FoxM1）与病理疾病分期显著相关。

Cytoplasmic Forkhead box M1 (FoxM1) in esophageal squamous cell carcinoma significantly correlates with pathological disease stage.

机构信息

Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong.

出版信息

World J Surg. 2012 Jan;36(1):90-7. doi: 10.1007/s00268-011-1302-5.

DOI:10.1007/s00268-011-1302-5
PMID:21976009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3243851/
Abstract

UNLABELLED

Esophageal cancer is a deadly cancer with esophageal squamous cell carcinoma (ESCC) as the major type. Until now there has been a lack of reliable prognostic markers for this malignancy. This study aims to investigate the clinical correlation between Forkhead box M1 (FoxM1)and patients' parameters in ESCC.

METHODS

Immunohistochemistry was performed to investigate the expression and localization of FoxM1 in 64ESCC tissues and 10 nontumor esophageal tissues randomly selected from 64 patients before these data were used for clinical correlations.

RESULTS

Cytoplasmic and nuclear expressions of FoxM1 were found in 63 and 16 of the 64 ESCC tissues, respectively.Low cytoplasmic expression of FoxM1 was correlated with early pathological stage in ESCC (P = 0.018),while patients with nuclear FoxM1 were younger in age than those without nuclear expression (P\0.001).Upregulation of FoxM1 mRNA was found in five ESCCcell lines (HKESC-1, HKESC-2, HKESC-3, HKESC-4,and SLMT-1) when compared to non-neoplastic esophageal squamous cell line NE-1 using quantitative polymerase chain reaction (qPCR). Except for HKESC-3, all studied ESCC cell lines demonstrated a high expression of FoxM1 protein using immunoblot. A high mRNA level of FoxM1 was observed in all of the ESCC tissues examined when compared to their adjacent nontumor tissues using qPCR.

CONCLUSION

Cytoplasmic FoxM1 was correlated with pathological stage and might be a biomarker for advanced ESCC.

摘要

未标记

食管癌是一种致命的癌症，以食管鳞状细胞癌（ESCC）为主。到目前为止，这种恶性肿瘤还缺乏可靠的预后标志物。本研究旨在探讨叉头框蛋白 M1（FoxM1）与 ESCC 患者参数之间的临床相关性。

方法

通过免疫组织化学法检测 64 例 ESCC 组织和 64 例患者随机选择的 10 例非肿瘤食管组织中 FoxM1 的表达和定位，然后对这些数据进行临床相关性分析。

结果

在 64 例 ESCC 组织中，FoxM1 的细胞质和核表达分别为 63 例和 16 例。FoxM1 的细胞质低表达与 ESCC 的早期病理分期相关（P=0.018），而核 FoxM1 阳性的患者年龄小于核 FoxM1 阴性的患者（P<0.001）。与非肿瘤性食管鳞状细胞系 NE-1 相比，用实时定量聚合酶链反应（qPCR）发现 5 种 ESCC 细胞系（HKESC-1、HKESC-2、HKESC-3、HKESC-4 和 SLMT-1）中 FoxM1 mRNA 上调。除 HKESC-3 外，所有研究的 ESCC 细胞系均通过免疫印迹显示 FoxM1 蛋白高表达。用 qPCR 检测所有检查的 ESCC 组织中 FoxM1 的 mRNA 水平均高于相邻的非肿瘤组织。

结论

细胞质 FoxM1 与病理分期相关，可能是晚期 ESCC 的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/77e0cf314e50/268_2011_1302_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/5bd7eb190321/268_2011_1302_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/058c717a0954/268_2011_1302_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/daddd0667810/268_2011_1302_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/cc41433d9b68/268_2011_1302_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/97821b354752/268_2011_1302_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/7971065b6fa3/268_2011_1302_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/a624c353ca20/268_2011_1302_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/77e0cf314e50/268_2011_1302_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/5bd7eb190321/268_2011_1302_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/7c5b07527010/268_2011_1302_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/058c717a0954/268_2011_1302_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/daddd0667810/268_2011_1302_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/cc41433d9b68/268_2011_1302_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/97821b354752/268_2011_1302_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/7971065b6fa3/268_2011_1302_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/a624c353ca20/268_2011_1302_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcfa/3243851/77e0cf314e50/268_2011_1302_Fig9_HTML.jpg

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