CUEDC2：炎症和肿瘤发生中的一个新兴关键调控因子。
CUEDC2: an emerging key player in inflammation and tumorigenesis.
机构信息
Institute of Basic Medical Sciences, National Center of Biomedical Analysis, Beijing 100850, China.
出版信息
Protein Cell. 2011 Sep;2(9):699-703. doi: 10.1007/s13238-011-1089-z. Epub 2011 Oct 6.
Abstract
CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors. CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibition. CUEDC2 is also known to interact with IkB kinase α (IKKα) and IKKβ and has an inhibitory role in the activation of transcription factor nuclear factor-κB. Moreover, CUEDC2 plays an important role in downregulating the expression of hormone receptors estrogen receptor-α and progesterone receptor, thereby impairing the responsiveness of breast cancer to endocrine therapies. In this review, current knowledge on the multi-functions of CUEDC2 in normal processes and tumorigenesis are discussed and summarized.
摘要
CUE 结构域包含蛋白 2（CUEDC2）是一种参与细胞周期调控、炎症和肿瘤发生的蛋白质，在许多类型的肿瘤中高度表达。CUEDC2 在有丝分裂期间被 Cdk1 磷酸化，并促进纺锤体检查点抑制复合物或周期素依赖性激酶激活物（APC/C）的释放。CUEDC2 还已知与 IkB 激酶α（IKKα）和 IKKβ相互作用，并在转录因子核因子-κB 的激活中起抑制作用。此外，CUEDC2 在下调激素受体雌激素受体-α和孕激素受体的表达方面发挥着重要作用，从而损害了乳腺癌对内分泌治疗的反应性。在这篇综述中，讨论并总结了 CUEDC2 在正常过程和肿瘤发生中的多种功能的最新知识。
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2
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3
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.NLRC5 负调控 NF-κB 和 I 型干扰素信号通路。
Cell. 2010 Apr 30;141(3):483-96. doi: 10.1016/j.cell.2010.03.040.
4
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Trends Biochem Sci. 2010 Aug;35(8):450-8. doi: 10.1016/j.tibs.2010.03.002. Epub 2010 May 1.
5
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Cell. 2010 Mar 19;140(6):883-99. doi: 10.1016/j.cell.2010.01.025.
6
Mitotic chromosomal instability and cancer: mouse modelling of the human disease.有丝分裂染色体不稳定性与癌症：人类疾病的小鼠模型。
Nat Rev Cancer. 2010 Feb;10(2):102-15. doi: 10.1038/nrc2781.
7
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Nat Rev Cancer. 2009 Sep;9(9):631-43. doi: 10.1038/nrc2713.
8
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9
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