系统性红斑狼疮或类风湿关节炎患者血清中针对α-1,6-葡聚糖的抗体水平升高。
Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis.
机构信息
Department of Immunology, Peking University Health Science Center, Peking University, Beijing 100083, China.
出版信息
Protein Cell. 2011 Sep;2(9):739-44. doi: 10.1007/s13238-011-1095-1. Epub 2011 Oct 6.
This study was undertaken to investigate whether levels of anti-alpha-1, 6-glucan antibodies in human sera correlate with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Serum samples were collected from patients with SLE (n = 30), RA (n = 30) and healthy adult volunteers. IgG, IgA and IgM levels against alpha-1, 6-glucan were measured using enzyme linked immunosorbent assays. Anti-alpha-1, 6-glucan IgG prevalence was raised in patients with active SLE (73.3%) and RA (60%) compared with healthy controls (13.3%). Strong correlation between anti-alpha-1,6-glucan-IgG levels and anti-perinuclear factor (r = 0.642; p < 0.05) in RA patients or anti-nuclear antibodies (r = 0.675; p < 0.05) in SLE patients was observed. No significant differences in anti-alpha-1,6-glucan-IgA or-IgM levels were noted between different groups. We conclude that anti-alpha-1,6-glucan-IgG levels were significantly elevated in patients with SLE or RA and positively correlated with disease activity.
本研究旨在探讨人血清中抗α-1,6-葡聚糖抗体水平是否与类风湿关节炎（RA）和系统性红斑狼疮（SLE）相关。采集 SLE 患者（n=30）、RA 患者（n=30）和健康成年志愿者的血清样本。采用酶联免疫吸附试验测定抗α-1,6-葡聚糖 IgG、IgA 和 IgM 水平。与健康对照组（13.3%）相比，活动期 SLE（73.3%）和 RA（60%）患者的抗α-1,6-葡聚糖 IgG 患病率升高。RA 患者抗α-1,6-葡聚糖-IgG 水平与抗核周因子（r=0.642；p<0.05）或 SLE 患者抗核抗体（r=0.675；p<0.05）呈强相关。不同组间抗α-1,6-葡聚糖-IgA 或-IgM 水平无显著差异。我们的结论是，SLE 或 RA 患者的抗α-1,6-葡聚糖 IgG 水平显著升高，并与疾病活动度呈正相关。
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