Department of Epidemiology and Health Statistics, College of Public Health, Zhejiang University, Hangzhou, Zhejiang, China.
Mol Carcinog. 2012 Oct;51 Suppl 1:E21-31. doi: 10.1002/mc.20863. Epub 2011 Oct 4.
To explore the associations of SNPs within hsa-miR-605 (rs2043556) and hsa-miR-149 (rs2292832) and lifestyle-related factors with gastrointestinal cancer, a case-control study including 762 cases and 757 controls was conducted. Marginally significant associations were found both for hsa-miR-149 rs2292832 with gastric cancer risk (TC + CC vs. TT, OR = 0.68, 95% CI: 0.44-1.04) and for hsa-miR-605 rs2043556 with colorectal cancer risk (AG + GG vs. AA, OR = 0.70, 95% CI: 0.48-1.02) in males. Tea drinking showed a protective effect on gastric cancer risk (OR = 0.28, 95% CI: 0.13-0.60), while smoke inhalation increased the risk of gastric cancer (OR = 1.94, 95% CI: 1.08-3.47). Irritability was found to be a risk factor for both colorectal cancer (OR = 1.61, 95% CI: 1.02-2.53) and gastric cancer (OR = 1.96, 95% CI: 1.17-3.29). Among those that engaged in smoke inhalation, miR-149 CT/CC and miR-605 AG/GG genotype carriers had increased susceptibilities to colorectal cancer (OR = 1.90, 95% CI: 1.11-3.25) and gastric cancer (OR = 1.87, 95% CI: 1.03-3.42), respectively. Among the tea drinkers, there exists a marginally protective effect of miR-605 AG/GG genotypes on colorectal cancer incidence (OR = 0.71, 95% CI: 0.47-1.06) and a significantly protective effect of miR-149 CT/CC on gastric cancer incidence (OR = 0.47, 95% CI: 0.29-0.77). The SNPs of rs2292832 and rs2043556 might be able to modify the susceptibility to male gastric and colorectal cancers, respectively. Tea drinking is a protective factor, while smoke inhalation is a risk factor for gastric cancer, and they might have the potential to modify the associations between miR-149 and miR-605 polymorphisms with gastrointestinal cancer risk. In addition, irritability was shown to be a risk factor for both gastric and colorectal cancers.
为了探索 hsa-miR-605（rs2043556）和 hsa-miR-149（rs2292832）中的 SNP 与生活方式相关因素与胃肠道癌症之间的关联，进行了一项包括 762 例病例和 757 例对照的病例对照研究。在男性中，hsa-miR-149 rs2292832 与胃癌风险（TC+CC 与 TT，OR=0.68，95%CI：0.44-1.04）和 hsa-miR-605 rs2043556 与结直肠癌风险（AG+GG 与 AA，OR=0.70，95%CI：0.48-1.02）之间存在显著的关联。饮茶对胃癌风险有保护作用（OR=0.28，95%CI：0.13-0.60），而吸入烟雾会增加胃癌风险（OR=1.94，95%CI：1.08-3.47）。易激惹被发现是结直肠癌（OR=1.61，95%CI：1.02-2.53）和胃癌（OR=1.96，95%CI：1.17-3.29）的危险因素。在那些吸烟的人中，miR-149 CT/CC 和 miR-605 AG/GG 基因型携带者易患结直肠癌（OR=1.90，95%CI：1.11-3.25）和胃癌（OR=1.87，95%CI：1.03-3.42）。在饮茶者中，miR-605 AG/GG 基因型对结直肠癌的发生有适度的保护作用（OR=0.71，95%CI：0.47-1.06），miR-149 CT/CC 对胃癌的发生有显著的保护作用（OR=0.47，95%CI：0.29-0.77）。rs2292832 和 rs2043556 的 SNP 可能分别能够修饰男性胃癌和结直肠癌的易感性。饮茶是一种保护因素，而吸烟是胃癌的危险因素，它们可能有潜力修饰 miR-149 和 miR-605 多态性与胃肠道癌症风险之间的关联。此外，易激惹被证明是胃癌和结直肠癌的危险因素。
