Department of Pathology, School of Medicine, University of California San Diego, USA.
Am J Trop Med Hyg. 2011 Oct;85(4):667-73. doi: 10.4269/ajtmh.2011.11-0123.
Trichomonas vaginalis and Tritrichomonas foetus cause common sexually transmitted infections in humans and cattle, respectively. Mouse models of trichomoniasis are important for pathogenic and therapeutic studies. Here, we compared murine genital infections with T. vaginalis and T. foetus. Persistent vaginal infection with T. foetus was established with 100 parasites but T. vaginalis infection required doses of 10(6), perhaps because of greater susceptibility to killing by mouse vaginal polymorphonuclear leukocytes. Infection with T. vaginalis persisted longest after combined treatment of mice with estrogen and dexamethasone, whereas infection was only short-lived when mice were given estrogen or dexamethasone alone, co-infected with Lactobacillus acidophilus, and/or pretreated with antibiotics. Infection rates were similar with metronidazole-resistant (MR) and metronidazole-sensitive (MS) T. vaginalis. High dose but not low dose metronidazole treatment controlled infection with MS better than MR T. vaginalis. These murine models will be valuable for investigating the pathogenesis and treatment of trichomoniasis.
阴道毛滴虫和胎儿三毛滴虫分别引起人类和牛的常见性传播感染。阴道毛滴虫病的小鼠模型对于发病机制和治疗研究非常重要。在这里，我们比较了 T. vaginalis 和 T. foetus 引起的小鼠生殖道感染。用 100 个虫体建立了 T. foetus 的持续性阴道感染，但 T. vaginalis 感染需要 10（6）个虫体，这可能是因为阴道多形核白细胞更容易杀死 T. vaginalis。当用雌激素和地塞米松联合处理小鼠时，T. vaginalis 的感染持续时间最长，而当小鼠单独用雌激素或地塞米松、与嗜酸乳杆菌共同感染或用抗生素预处理时，感染时间很短。耐甲硝唑（MR）和甲硝唑敏感（MS）T. vaginalis 的感染率相似。高剂量而非低剂量甲硝唑治疗对 MS T. vaginalis 的控制效果优于 MR T. vaginalis。这些小鼠模型将有助于研究阴道毛滴虫病的发病机制和治疗方法。
