Virology and Experimental Therapy Laboratory, Aggeu Magalhães Research Center, Fiocruz, Recife, Pernambuco, Brazil.
Am J Trop Med Hyg. 2011 Oct;85(4):739-47. doi: 10.4269/ajtmh.2011.10-0496.
From September 2005 to March 2007, 238 individuals being vaccinated for the first time with the yellow fever (YF) -17DD vaccine were enrolled in a cohort established in Recife, Brazil. A prospective study indicated that, after immunization, anti-YF immunoglobulin M (IgM) and anti-YF IgG were present in 70.6% (IgM) and 98.3% (IgG) of the vaccinated subjects. All vaccinees developed protective immunity, which was detected by the plaque reduction neutralization test (PRNT) with a geometric mean titer of 892. Of the 238 individuals, 86.6% had IgG antibodies to dengue virus; however, the presence of anti-dengue IgG did not interfere significantly with the development of anti-YF neutralizing antibodies. In a separate retrospective study of individuals immunized with the 17DD vaccine, the PRNT values at 5 and 10 years post-vaccination remained positive but showed a significant decrease in neutralization titer (25% with PRNT titers < 100 after 5 years and 35% after 10 years).
从 2005 年 9 月至 2007 年 3 月，238 名首次接种黄热病（YF）-17DD 疫苗的个体被纳入在巴西累西腓建立的队列中。一项前瞻性研究表明，免疫接种后，70.6%（IgM）和 98.3%（IgG）的接种者体内存在抗 YF 免疫球蛋白 M（IgM）和抗 YF IgG。所有疫苗接种者均产生了保护性免疫，这通过蚀斑减少中和试验（PRNT）检测到，几何平均滴度为 892。在 238 名个体中，86.6%的个体对登革热病毒具有 IgG 抗体；然而，抗登革热 IgG 的存在并未显著干扰抗 YF 中和抗体的产生。在对 17DD 疫苗进行免疫接种的个体的另一项回顾性研究中，接种后 5 年和 10 年的 PRNT 值仍为阳性，但中和滴度显著下降（5 年后 PRNT 滴度<100 的为 25%，10 年后为 35%）。
