Centro de Investigação em Saúde de Manhiça, Mozambique.
Am J Trop Med Hyg. 2011 Oct;85(4):776-81. doi: 10.4269/ajtmh.2011.10-0713.
T cell activation and depletion of naive T cells are hallmarks of human immunodeficiency virus (HIV) pathogenesis. This study explored the relationships between certain co-infections (including syphilis, hepatitis B and C, human T cell lymphotrophic viruses I and II [HTLV-I/II], Kaposi sarcoma-associated herpesvirus [KSHV], Plasmodium falciparum malaria, and tuberculosis), and levels of activated CD8 and CD4 T cell subsets as well as naive and memory CD4 T cells in HIV-infected adults in a rural area of southern Mozambique. We found that syphilis infection and to a lesser extent HTLV-I/II seropositivity were independently associated with higher CD8 T cell activation (CD8+ CD38+ HLA-DR+) whereas only syphilis was associated with higher CD4 T cell activation. Furthermore, KSHV and HTLV-I/II seropositivities were independently associated with a lower percentage of naive CD4 T cells (CD4+ CD45RA+ CD62L+). These results highlight the importance of screening and prompt treatment of syphilis, and raise questions as to whether HIV-positive persons with certain chronic viral co-infections should initiate combined antiretroviral therapy at higher CD4 cell counts.
T 细胞激活和幼稚 T 细胞耗竭是人类免疫缺陷病毒（HIV）发病机制的标志。本研究探讨了某些合并感染（包括梅毒、乙型和丙型肝炎、人类 T 细胞嗜淋巴细胞病毒 I 和 II[HTLV-I/II]、卡波西肉瘤相关疱疹病毒[KSHV]、疟原虫恶性疟和结核）与 HIV 感染成年人中激活的 CD8 和 CD4 T 细胞亚群以及幼稚和记忆 CD4 T 细胞水平之间的关系，该研究在莫桑比克南部的一个农村地区进行。我们发现梅毒感染（以及在较小程度上 HTLV-I/II 阳性）与 CD8 T 细胞激活（CD8+ CD38+ HLA-DR+）升高独立相关，而只有梅毒与 CD4 T 细胞激活升高相关。此外，KSHV 和 HTLV-I/II 阳性与较低比例的幼稚 CD4 T 细胞（CD4+ CD45RA+ CD62L+）独立相关。这些结果强调了筛查和及时治疗梅毒的重要性，并提出了一个问题，即是否应在更高的 CD4 细胞计数时，对存在某些慢性病毒合并感染的 HIV 阳性者启动联合抗逆转录病毒治疗。
