State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Org Lett. 2011 Nov 4;13(21):5824-6. doi: 10.1021/ol2024339. Epub 2011 Oct 6.
A highly stereoselective asymmetric 1,4-addition of diarylphosphines to α,β-unsaturated aldehydes catalyzed by a bis(phosphine) pincer-Pd complex has been developed for the synthesis of chiral phosphines with excellent stereoselectivity (up to 98% ee) under mild conditions. The application of the current method to the synthesis of enantiopure bisphosphine and its pincer-Pd complex has also been demonstrated.
一种双(膦)钳钯配合物催化的二芳基膦对α,β-不饱和醛的高对映选择性 1,4-加成反应已被开发出来，用于在温和条件下以优异的对映选择性（高达 98%ee）合成手性膦。该方法在手性双膦及其钳钯配合物的合成中的应用也得到了证明。
