Utian W H
Case Western Reserve University, Cleveland, Ohio 44106.
Ann N Y Acad Sci. 1990;592:1-7. doi: 10.1111/j.1749-6632.1990.tb30310.x.
This article attempts to survey our current understanding of the human female climacteric and the role of hormone replacement in its treatment. As a potential endocrinopathy, the climacteric deserves appropriate diagnostic recognition and selective preventive pharmacotherapy. The impact of sometimes conflicting influences such as nutritional, dietary or lifestyle changes, exercise, smoking, drugs, alcohol and other medications, all need differentiation from true hormonal responses. The climacteric, one syndrome occurring over a period of time, has potentially lethal effects, notably coronary heart disease and complications of osteoporotic fractures. However, therapy itself carries major problems, the cancer question being the most important. The dilemma of risk-benefit planning is reviewed and likely future developments are outlined. The role of the new North American Menopause Society is explained.
本文试图概述我们目前对人类女性更年期以及激素替代疗法在其治疗中的作用的理解。作为一种潜在的内分泌疾病，更年期值得得到适当的诊断识别和选择性预防性药物治疗。营养、饮食或生活方式改变、运动、吸烟、药物、酒精及其他药物等有时相互冲突的影响，都需要与真正的激素反应相区分。更年期是在一段时间内出现的一种综合征，具有潜在的致命影响，尤其是冠心病和骨质疏松性骨折的并发症。然而，治疗本身也存在重大问题，癌症问题最为重要。本文回顾了风险-效益规划的困境，并概述了未来可能的发展。文中还解释了北美更年期协会的新作用。
