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本文引用的文献

1
Compensatory growth factor and cytokine response in tears after subconjunctival bevacizumab injection.结膜下注射贝伐单抗后泪液中补偿性生长因子和细胞因子反应。
Cornea. 2011 Oct;30(10):1071-7. doi: 10.1097/ICO.0b013e31820cd3f4.
2
Consensus statement on indications for anti-angiogenic therapy in the management of corneal diseases associated with neovascularisation: outcome of an expert roundtable.关于抗血管生成治疗在新生血管相关性角膜疾病管理中的适应证的专家共识声明：专家圆桌会议的结果。
Br J Ophthalmol. 2012 Jan;96(1):3-9. doi: 10.1136/bjo.2011.204701. Epub 2011 Jun 28.
3
Combined use of subconjunctival and intracorneal bevacizumab injection for corneal neovascularization.联合应用结膜下和角膜内注射贝伐单抗治疗角膜新生血管。
Cornea. 2011 Oct;30(10):1110-4. doi: 10.1097/ICO.0b013e31821379aa.
4
Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids.局部应用皮质类固醇抑制炎性角膜淋巴管生成。
Arch Ophthalmol. 2011 Apr;129(4):445-52. doi: 10.1001/archophthalmol.2011.42.
5
[Antiangiogenic therapy at the ocular surface: when, what and why?].[眼表的抗血管生成治疗：时机、方法及原因？]
Ophthalmologe. 2011 Mar;108(3):230-6. doi: 10.1007/s00347-010-2262-0.
6
Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody.血管生成素-1 抑制在抑制血管生成和肿瘤生长中的上下文相关作用：AMG 386，一种血管生成素-1/2 中和肽抗体的意义。
Mol Cancer Ther. 2010 Oct;9(10):2641-51. doi: 10.1158/1535-7163.MCT-10-0213.
7
Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis.角膜新生血管是角膜移植术后移植物失败和排斥的危险因素：一项基于证据的荟萃分析。
Ophthalmology. 2010 Jul;117(7):1300-5.e7. doi: 10.1016/j.ophtha.2010.01.039. Epub 2010 Jun 3.
8
Inhibition of corneal neovascularization by topical bevacizumab (Anti-VEGF) and Sunitinib (Anti-VEGF and Anti-PDGF) in an animal model.在动物模型中，局部应用贝伐单抗（抗 VEGF）和舒尼替尼（抗 VEGF 和抗 PDGF）抑制角膜新生血管形成。
Am J Ophthalmol. 2010 Oct;150(4):519-528.e1. doi: 10.1016/j.ajo.2010.04.024. Epub 2010 Jun 29.
9
Ocular angiogenesis: mechanisms and recent advances in therapy.眼部血管生成：机制与治疗新进展。
Adv Clin Chem. 2010;50:103-21.
10
The different effects of early and late bevacizumab (Avastin) injection on inhibiting corneal neovascularization and conjunctivalization in rabbit limbal insufficiency.早期和晚期贝伐单抗（阿瓦斯汀）注射抑制兔角膜缘不全的角膜新生血管和结膜化的不同作用。
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6277-85. doi: 10.1167/iovs.09-4571. Epub 2010 Apr 30.

新兴技术治疗角膜新生血管。

Emerging techniques to treat corneal neovascularisation.

机构信息

Institute of Ophthalmology, University College London, London, UK.

出版信息

Eye (Lond). 2012 Jan;26(1):2-12. doi: 10.1038/eye.2011.246. Epub 2011 Oct 7.

DOI:10.1038/eye.2011.246
PMID:21979862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3259583/
Abstract

Neovascularisation is a major cause of visual loss in a number of ophthalmic diseases. This review aims to outline the basic regulators of vessel growth in corneal neovascularisation. An understanding of the underlying principles of physiological and pathophysiological vascular development helps to appreciate current approaches to prevent or treat corneal neovascularisation. Options for future interventions will be discussed in the light of recent evidence provided by animal models of corneal neovascularisation.

摘要

新生血管形成是许多眼科疾病导致视力丧失的主要原因。本综述旨在概述角膜新生血管形成中血管生长的基本调节因子。了解生理性和病理性血管发育的基本原理有助于理解当前预防或治疗角膜新生血管形成的方法。根据角膜新生血管形成的动物模型提供的最新证据，讨论未来干预措施的选择。