Institute of Ophthalmology, University College London, London, UK.
Eye (Lond). 2012 Jan;26(1):2-12. doi: 10.1038/eye.2011.246. Epub 2011 Oct 7.
Neovascularisation is a major cause of visual loss in a number of ophthalmic diseases. This review aims to outline the basic regulators of vessel growth in corneal neovascularisation. An understanding of the underlying principles of physiological and pathophysiological vascular development helps to appreciate current approaches to prevent or treat corneal neovascularisation. Options for future interventions will be discussed in the light of recent evidence provided by animal models of corneal neovascularisation.
新生血管形成是许多眼科疾病导致视力丧失的主要原因。本综述旨在概述角膜新生血管形成中血管生长的基本调节因子。了解生理性和病理性血管发育的基本原理有助于理解当前预防或治疗角膜新生血管形成的方法。根据角膜新生血管形成的动物模型提供的最新证据,讨论未来干预措施的选择。