角膜血管生成特权及其失败。
Corneal angiogenic privilege and its failure.
机构信息
Ophthalmology Operative Complex Unit, University Campus Bio-Medico, Rome, Italy.
Ophthalmology Operative Complex Unit, University Campus Bio-Medico, Rome, Italy.
出版信息
Exp Eye Res. 2021 Mar;204:108457. doi: 10.1016/j.exer.2021.108457. Epub 2021 Jan 22.
Abstract
The cornea actively maintains its own avascular status to preserve its ultimate optical function. This corneal avascular state is also defined as "corneal angiogenic privilege", which results from a critical and sensitive balance between anti-angiogenic and pro-angiogenic mechanisms. In our review, we aim to explore the complex equilibrium among multiple mediators which prevents neovascularization in the resting cornea, as well as to unveil the evolutive process which leads to corneal angiogenesis in response to different injuries.
摘要
角膜通过主动维持自身无血管状态来保持其最终光学功能。这种角膜无血管状态也被定义为“角膜血管生成特权”，这是由于抗血管生成和促血管生成机制之间的关键和敏感平衡所致。在我们的综述中，我们旨在探讨阻止静止角膜新生血管形成的多种介质之间的复杂平衡，以及揭示导致角膜对不同损伤发生血管生成的演变过程。
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