College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea.
Planta Med. 2012 Jan;78(2):177-81. doi: 10.1055/s-0031-1280265. Epub 2011 Oct 6.
Activity-directed isolation of the ethyl acetate fraction from the roots of Rubia cordifolia resulted in the identification of a new anthraquinone, 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone-3- O- α- L-rhamnopyranosyl-(1 → 2)- β-D-(6'-O-acetyl)-glucopyranoside (1), two new dihydronaphtoquinones, 1,4-dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O- β-D-glucopyranoside (2) and mollugin-1-O- β- D-glucopyranoside (3), and a new monoterpenoid, 3 R,3a S,4 R,6a R-3,4,6-tris(hydroxymethyl)-3,3a,4,6a-tetrahydro-2 H-cyclopenta[ B]furan-2-one (4), together with nine known compounds (5-13). The structures of these compounds were elucidated on the basis of spectroscopic evidence. In addition, their DNA topoisomerases I and II inhibitory activity and cytotoxicity were measured.
从茜草的根部分离到的乙酸乙酯部分经活性导向分离得到一个新的蒽醌类化合物，1,3,6-三羟基-2-羟甲基-9,10-蒽醌-3-O-α-L-鼠李吡喃糖基-(1→2)-β-D-(6'-O-乙酰基)-吡喃葡萄糖苷（1），两个新的二氢萘醌类化合物，1,4-二羟基-2-甲氧基-3-丙烯基萘-1-O-β-D-吡喃葡萄糖苷（2）和莫诺苷-1-O-β-D-吡喃葡萄糖苷（3），以及一个新的单萜类化合物，3R,3aS,4R,6aR-3,4,6-三（羟甲基）-3,3a,4,6a-四氢-2H-环戊[B]呋喃-2-酮（4），此外，还分离得到了 9 个已知化合物（5-13）。这些化合物的结构是基于光谱证据确定的。此外，还测定了它们对 DNA 拓扑异构酶 I 和 II 的抑制活性和细胞毒性。
