School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
J Virol. 2011 Nov;85(21):11540-1. doi: 10.1128/JVI.06051-11.
As one of the first five human adenoviruses (HAdVs) to be sequenced, type 17 was important as a reference tool for comparative genomics of recently isolated HAdV pathogens in species D. HAdV-D17 was the first species D adenovirus to be sequenced and was deposited in GenBank in 1999. These genome data were not of high quality, and a redetermination of the same stock virus provides corrected data; among the differences are a length of 35,139 bp versus 35,100 bp in the original, and 160 mismatches to the original genome were found. Annotation of the coding sequences reveals 39 as opposed to 8, a finding which is important for phylogenomic studies.
作为最早测序的五种人类腺病毒（HAdVs）之一，17 型是研究种 D 中最近分离的 HAdV 病原体比较基因组学的重要参考工具。HAdV-D17 是第一个被测序的种 D 腺病毒，于 1999 年在 GenBank 中注册。这些基因组数据质量不高，重新确定同一库存病毒提供了更正的数据；其中差异包括长度为 35139bp 对原始长度 35100bp，以及与原始基因组有 160 个错配。对编码序列的注释显示有 39 个，而不是 8 个，这一发现对系统基因组学研究很重要。
