体外神经递质的波长正交光解。
Wavelength-orthogonal photolysis of neurotransmitters in vitro.
机构信息
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
出版信息
Chem Commun (Camb). 2012 Jan 18;48(5):657-9. doi: 10.1039/c1cc15135e. Epub 2011 Oct 7.
PMID:21980596
Abstract
Irradiation of a mixture of 4-methoxyphenacyl-caged (S)-glutamate and 4,5-dimethoxy-2-nitrobenzyl-caged γ-amino butyric acid (GABA) on neurons, at ~260 nm, evokes selective photorelease of (S)-glutamate (Glu) whereas photolysis at 405 nm causes selective photorelease of GABA.
摘要
用 260nm 左右的光辐照 4-甲氧基苯甲酰基-（S）-谷氨酸和 4,5-二甲氧基-2-硝基苄基-γ-氨基丁酸（GABA）的混合物在神经元上，可选择性地释放（S）-谷氨酸（Glu），而 405nm 的光解则会选择性地释放 GABA。
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