Buchbinder A
Veterans Affairs Medical Center, Manhattan, NY.
Ear Nose Throat J. 1990 Jun;69(6):376, 379-84.
Understanding the mode of replication of the human immunodeficiency virus (HIV) is necessary for explaining the natural history of HIV infection and for the development of therapeutic and prophylactic agents. The life cycle of HIV involves infective particles, the attachment of the virus to specific cell receptors, reverse transcription of the viral RNA into DNA by using viral encoded enzymes, integration of the viral DNA into the host genome, use of the host machinery to transcribe and translate viral genes, and the formation of budding particles. Viral encoded genes, regulated by a complex interaction of viral and host proteins with viral sequences, ultimately encode for the viral structural proteins, regulatory proteins, and enzymes necessary for the formation of mature infectious particles. Blocking one or more steps in the viral life cycle and preventing enhancement of virus production are important approaches in the control of HIV.
了解人类免疫缺陷病毒（HIV）的复制模式对于解释HIV感染的自然史以及开发治疗和预防药物至关重要。HIV的生命周期包括感染性颗粒、病毒与特定细胞受体的附着、利用病毒编码的酶将病毒RNA逆转录为DNA、病毒DNA整合到宿主基因组中、利用宿主机制转录和翻译病毒基因以及出芽颗粒的形成。由病毒和宿主蛋白与病毒序列的复杂相互作用调控的病毒编码基因最终编码病毒结构蛋白、调节蛋白以及形成成熟感染性颗粒所需的酶。阻断病毒生命周期中的一个或多个步骤并防止病毒产生的增强是控制HIV的重要方法。
