Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Mycoses. 2012 Jul;55(4):352-6. doi: 10.1111/j.1439-0507.2011.02124.x. Epub 2011 Oct 10.
Zygomycosis, or mucormycosis, is associated with significant morbidity and mortality in both children and adults. Studies in adults have shown an increase in the incidence of zygomycosis, particularly among haemtopoietic stem cell transplant (HSCT) recipients and patients with haematologic malignancies. There is a paucity of data on the epidemiology of zygomycosis in children. We performed a retrospective analysis to describe trends in zygomycosis between 1 January 2003 and 31 December 2010. We used the Pediatric Health Information System (PHIS) database to identify paediatric patients who were diagnosed with zygomycosis during the study period. Administrative data on diagnoses, demographics, underlying conditions and clinical experiences were collected. Summary statistics were calculated and tests for trend were conducted. We identified 156 unique patients with zygomycosis. The prevalence of zygomycosis did not significantly increase over time (P=0.284). The most common underlying condition was malignancy (58%) and over half received intensive care. Voriconazole utilisation among all hospitalised children significantly increased during the period (P=0.010). Our study demonstrates that the incidence of zygomycosis is not significantly increasing. During the time period there was a significant increase in the use of voriconazole among children.
接合菌病，又称毛霉病，在儿童和成人中均与较高的发病率和死亡率相关。成人研究表明，接合菌病的发病率有所增加，尤其是造血干细胞移植（HSCT）受者和血液恶性肿瘤患者。儿童接合菌病的流行病学数据很少。我们进行了一项回顾性分析，以描述 2003 年 1 月 1 日至 2010 年 12 月 31 日期间接合菌病的趋势。我们使用儿科健康信息系统（PHIS）数据库来识别研究期间被诊断为接合菌病的儿科患者。收集了关于诊断、人口统计学、基础疾病和临床经验的管理数据。计算了汇总统计数据并进行了趋势检验。我们确定了 156 例独特的接合菌病患者。接合菌病的患病率并未随时间显著增加（P=0.284）。最常见的基础疾病是恶性肿瘤（58%），超过一半的患者接受了重症监护。在此期间，所有住院儿童中伏立康唑的使用率显著增加（P=0.010）。我们的研究表明，接合菌病的发病率没有显著增加。在此期间，儿童中伏立康唑的使用率显著增加。
