Bloch Deborah, Gonzalez Mark D, Haight Ann, Abramowsky Carlos, Yildirim Inci
Department of Pediatric Infectious Diseases, Emory University, Atlanta, Georgia.
Microbiology Laboratory, Children's Healthcare of Atlanta, Atlanta, Georgia.
Pediatr Transplant. 2018 Dec;22(8):e13294. doi: 10.1111/petr.13294. Epub 2018 Sep 23.
Necrotizing fasciitis is a life-threatening, rapidly progressing infection of fascia and subcutaneous cellular tissue typically caused by mixed aerobic and anaerobic bacteria. We present a case report of an immunocompromised 4-year-old female with necrotizing fasciitis from a rare fungal organism, Mucor indicus. The patient underwent multiple debridements and was treated for 10 months, first on liposomal amphotericin B (2 months) then posaconazole (8 months). Mucor indicus is a rarely described pathogen with only nine other cases described. Identification of this organism remains a challenge, and the need for further understanding of risk factors and organism susceptibility testing to help guide treatment is crucial.
坏死性筋膜炎是一种危及生命、进展迅速的筋膜和皮下蜂窝组织感染，通常由需氧菌和厌氧菌混合感染引起。我们报告一例免疫功能低下的4岁女性坏死性筋膜炎病例，其病原菌为一种罕见的真菌——印度毛霉。该患者接受了多次清创手术，并接受了10个月的治疗，最初使用脂质体两性霉素B治疗2个月，然后使用泊沙康唑治疗8个月。印度毛霉是一种很少被描述的病原体，此前仅另有9例病例报道。识别这种病原体仍然是一项挑战，进一步了解危险因素和进行病原体药敏试验以指导治疗至关重要。
