Dolata J
Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
Eur Respir J. 1990 May;3(5):559-65.
Inflammatory mediators are released in the airways during both inflammatory and allergic reactions, and many of these mediators affect mucociliary activity. To discover whether mucociliary activity is changed by a combination of mediators, the interaction between prostaglandins and histamine or methacholine was studied in vivo in the rabbit maxillary sinus. We used a photoelectric technique and recorded frequency changes induced by tested substances. Prostaglandins E1 and F2 alpha (PGE1 and PGF2 alpha) were given as ia. infusions followed by bolus injections of histamine or methacholine. Infusion with PGE1 (0.1 microgram.kg-1) enhanced the stimulating effect of a subsequent injection of histamine (10 micrograms.kg-1), maximum stimulation being 33 +/- 6% compared to 14 +/- 4% after histamine alone (p = 0.02). When the histamine injection was given 20 min after PGE1 no enhancement was observed. PGE1 did not enhance the stimulating effect of methacholine. In contrast to PGE1, PGF2 alpha failed to enhance the effect of histamine. It is proposed that a role of PGE1 is to modify the mucociliary response to other mediators released during inflammatory and allergic reactions.
在炎症反应和过敏反应期间，气道中会释放炎症介质，其中许多介质会影响黏液纤毛活动。为了探究黏液纤毛活动是否会因介质组合而改变，我们在兔上颌窦体内研究了前列腺素与组胺或乙酰甲胆碱之间的相互作用。我们采用光电技术，并记录受试物质引起的频率变化。前列腺素E1和F2α（PGE1和PGF2α）通过腹腔注射给药，随后推注组胺或乙酰甲胆碱。注射PGE1（0.1微克·千克⁻¹）可增强随后注射组胺（10微克·千克⁻¹）的刺激作用，最大刺激为33±6%，而单独注射组胺后为14±4%（p = 0.02）。当在PGE1注射20分钟后注射组胺时，未观察到增强作用。PGE1并未增强乙酰甲胆碱的刺激作用。与PGE1相反，PGF2α未能增强组胺的作用。有人提出，PGE1的作用是改变黏液纤毛对炎症反应和过敏反应期间释放的其他介质的反应。
