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阿尔茨海默病存在时的路易小体。

Lewy bodies in the presence of Alzheimer's disease.

作者信息

Rosenblum W I, Ghatak N R

出版信息

Arch Neurol. 1979 Mar;36(3):170-1. doi: 10.1001/archneur.1979.00500390088011.

DOI:10.1001/archneur.1979.00500390088011
PMID:219817
Abstract

Large numbers of Lewy bodies in the substantia nigra were found in a case of Alzheimer's disease. Parkinsonian symptoms were not recognized. The patient appears to be an example of an association recognized by Woodard but not yet understood. The case is discussed in the context of reported relationships between Parkinson's disease or "Lewy body disease" and dementia, on the one hand, and reports linking various forms of psychoses with an unusually high incidence of Lewy bodies, on the other.

摘要

在一例阿尔茨海默病患者的黑质中发现了大量路易小体。未发现帕金森氏症状。该患者似乎是伍达德所确认但尚未被理解的一种关联的实例。本文在帕金森病或“路易体病”与痴呆之间已报道的关系,以及各种形式的精神病与路易小体异常高发生率之间的报道这两个背景下对该病例进行了讨论。

相似文献

1
Lewy bodies in the presence of Alzheimer's disease.阿尔茨海默病存在时的路易小体。
Arch Neurol. 1979 Mar;36(3):170-1. doi: 10.1001/archneur.1979.00500390088011.
2
A pathological study of the association between Lewy body disease and Alzheimer's disease.路易体病与阿尔茨海默病关联的病理学研究
J Neurol Neurosurg Psychiatry. 1989 Jun;52(6):701-8. doi: 10.1136/jnnp.52.6.701.
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A pathological study of the association between Lewy body disease and Alzheimer's disease.路易体病与阿尔茨海默病关联的病理学研究。
Adv Neurol. 1990;53:55-9.
4
Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.弥漫性路易体病:运用抗泛素免疫细胞化学的相关神经病理学研究
J Neurol Neurosurg Psychiatry. 1989 Nov;52(11):1236-47. doi: 10.1136/jnnp.52.11.1236.
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An electron microscopic study on atypical presenile dementia with numerous Lewy bodies in the cerebral cortex.大脑皮质有大量路易小体的非典型早老性痴呆的电子显微镜研究
Folia Psychiatr Neurol Jpn. 1982;36(1):99-106. doi: 10.1111/j.1440-1819.1982.tb00260.x.
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Progressive dementia with "diffuse Lewy-type inclusions' in cerebral cortex. A case report.伴有大脑皮质“弥漫性路易体样包涵体”的进行性痴呆。病例报告。
Arch Psychiatr Nervenkr (1970). 1980;228(3):243-8. doi: 10.1007/BF00342349.
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Cortical Lewy body dementia: clinical features and classification.皮质路易体痴呆:临床特征与分类
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The Lewy body in Parkinson's disease.帕金森病中的路易小体。
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The relationship of Alzheimer-type pathology to dementia in Parkinson's disease.阿尔茨海默病型病理与帕金森病痴呆的关系。
J Neural Transm Suppl. 1997;49:23-31. doi: 10.1007/978-3-7091-6844-8_3.
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Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: possible index of early neuropathology.帕金森病、路易体痴呆和阿尔茨海默病中尼古丁结合位点的改变:早期神经病理学的可能指标。
Neuroscience. 1995 Jan;64(2):385-95. doi: 10.1016/0306-4522(94)00410-7.

引用本文的文献

1
Translocator protein in late stage Alzheimer's disease and Dementia with Lewy bodies brains.晚期阿尔茨海默病和路易体痴呆脑的转位蛋白。
Ann Clin Transl Neurol. 2019 Aug;6(8):1423-1434. doi: 10.1002/acn3.50837. Epub 2019 Jul 9.
2
Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy.强直性肌营养不良症中的脑病理学:当tau蛋白病遇上剪接病和RNA病。
Front Mol Neurosci. 2014 Jan 9;6:57. doi: 10.3389/fnmol.2013.00057.
3
Imaging improves diagnosis of dementia with lewy bodies.影像学提高路易体痴呆的诊断。
Psychiatry Investig. 2009 Dec;6(4):233-40. doi: 10.4306/pi.2009.6.4.233. Epub 2009 Nov 21.
4
Diffuse Lewy body disease: clinical features in nine cases without coexistent Alzheimer's disease.弥漫性路易体病:9例无并存阿尔茨海默病患者的临床特征
J Neurol Neurosurg Psychiatry. 1996 May;60(5):531-8. doi: 10.1136/jnnp.60.5.531.
5
Atypical senile dementia with widespread Lewy type inclusion in the cerebral cortex.大脑皮质广泛存在路易体样包涵体的非典型老年痴呆症。
Acta Neuropathol. 1980;49(3):187-91. doi: 10.1007/BF00707105.
6
The rostral mesencephalon in Parkinson's disease and Alzheimer's disease.帕金森病和阿尔茨海默病中的中脑喙部
Acta Neuropathol. 1985;68(1):53-8. doi: 10.1007/BF00688956.
7
Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques.弥漫性路易体病:老年斑的光镜和电镜免疫细胞化学研究
Acta Neuropathol. 1989;78(6):572-84. doi: 10.1007/BF00691284.