Hunter S
Acta Neuropathol. 1985;68(1):53-8. doi: 10.1007/BF00688956.
The rostal mesencephalon at the level of the posterior commissure was studied by light microscopy in two patients with idiopathic Parkinson's disease, one patient with Alzheimer's disease, and one patient with senile dementia of Alzheimer's type. In the Parkinsonian cases, the rostral part of the nucleus of Edinger Westphal disclosed Lewy bodies in 3% of the neurons, neurofibrillary degeneration in 2% of the neurons, and a 54% neuronal loss. In Alzheimer's disease, 2% of Edinger Westphal neurons contained neurofibrillary degeneration, whereas in senile dementia of Alzheimer's type only rare neurofibrillary degeneration was evident in this nucleus. Neuronal loss was not apparent in the nucleus of Edinger Westphal in either of the Alzheimer's cases. The pathologic changes observed in this presumably cholinergic nucleus resemble in some respects changes reported in the cholinergic centers of the basal forebrain in these diseases. In addition, the central gray matter and pretectal region in Parkinson's disease contained a patchy increase in astroglia, some with scant reactive cell bodies; however, Lewy bodies were limited to that part of the central gray matter corresponding to the nucleus of Darkschewitsch. A few neurofibrillary tangles were present in the nucleus of Darkschewitsch in both diseases.
通过光学显微镜对两名特发性帕金森病患者、一名阿尔茨海默病患者和一名阿尔茨海默型老年痴呆症患者后连合水平的嘴侧中脑进行了研究。在帕金森病病例中，动眼神经核的嘴侧部分有3%的神经元出现路易小体，2%的神经元出现神经原纤维变性，神经元丢失率为54%。在阿尔茨海默病中，2%的动眼神经核神经元存在神经原纤维变性，而在阿尔茨海默型老年痴呆症中，该核中仅可见罕见的神经原纤维变性。在这两例阿尔茨海默病病例中，动眼神经核均未出现明显的神经元丢失。在这个可能为胆碱能的核中观察到的病理变化在某些方面类似于这些疾病中基底前脑胆碱能中心所报告的变化。此外，帕金森病患者的中央灰质和顶盖前区星形胶质细胞呈斑片状增多，部分细胞体反应性不强；然而，路易小体仅限于与达克谢维奇核相对应的中央灰质部分。两种疾病的达克谢维奇核中均存在少量神经原纤维缠结。
