Hong Minyoung, Park Sarah S, Do Hyunkyung, Jhon Gil-ja, Suh Minah, Lee Youngmi
Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea.
J Acupunct Meridian Stud. 2011 Sep;4(3):159-63. doi: 10.1016/j.jams.2011.09.002. Epub 2011 Oct 1.
Murine melanoma requires the complex development of lymphatic, vascular, and non-vascular structures. A possible relationship between the primo vascular system (PVS) and the melanoma metastasis has been proposed. In particular, the PVS may be involved in oxygen transport. Vasculogenic-like networks, similar to the PVS, have been found within melanoma tumors, but their functional relationship with the PVS and meridian structures are unclear. Herein, we report on the use of an electrochemical O(2) sensor to study oxygenation levels of melanoma tumors in mice. We consistently found higher tissue oxygenation in specific sites of tumors (n=5). These sites were strongly associated with vascular structures or the PVS. Furthermore, the PVS on the tumor surface was associated with adipose tissue. Our findings suggest that the PVS is involved in the regulation of metastasis.
小鼠黑色素瘤需要淋巴管、血管和非血管结构的复杂发育。有人提出了初级血管系统（PVS）与黑色素瘤转移之间的可能关系。特别是，PVS可能参与氧气运输。在黑色素瘤肿瘤内发现了类似于PVS的血管生成样网络，但其与PVS和经络结构的功能关系尚不清楚。在此，我们报告使用电化学O(2)传感器研究小鼠黑色素瘤肿瘤的氧合水平。我们始终在肿瘤的特定部位（n = 5）发现较高的组织氧合。这些部位与血管结构或PVS密切相关。此外，肿瘤表面的PVS与脂肪组织有关。我们的研究结果表明，PVS参与转移的调节。
