Department of Pediatrics, Yale University School of Medicine, PO Box 208064, New Haven, CT 6520, USA.
Pediatr Clin North Am. 2011 Oct;58(5):1241-55, xi. doi: 10.1016/j.pcl.2011.07.005.
The worldwide epidemic of childhood obesity in the last decades is responsible for the occurrence in pediatrics of disorders once mainly found in adults, such as the metabolic syndrome. A key factor in the pathogenesis of metabolic syndrome is insulin resistance, a phenomenon occurring mainly in obese subjects with a general resistance to the insulin effect only on carbohydrates metabolism. Given that the metabolic syndrome is driven by obesity, the prevalence of the latter will strongly influence the prevalence of metabolic syndrome. This article addresses the causes of metabolic syndrome and the relevance of obesity in the pediatric population.
在过去几十年中，全球儿童肥胖症的流行导致儿科中出现了以前主要在成年人中发现的疾病，例如代谢综合征。代谢综合征发病机制中的一个关键因素是胰岛素抵抗，这种现象主要发生在肥胖者中，他们对碳水化合物代谢的胰岛素作用普遍存在抵抗。由于代谢综合征是由肥胖引起的，后者的流行将强烈影响代谢综合征的流行。本文讨论了代谢综合征的原因和肥胖在儿科人群中的相关性。
