孕早期补充叶酸与儿童 6 岁时哮喘的关系。
Folic acid supplementation in early pregnancy and asthma in children aged 6 years.
机构信息
Yale Center for Perinatal, Pediatric, and Environmental Epidemiology, Yale School of Public Health, New Haven, CT 06510, USA.
出版信息
Am J Obstet Gynecol. 2012 Jan;206(1):72.e1-7. doi: 10.1016/j.ajog.2011.07.033. Epub 2011 Jul 29.
Abstract
OBJECTIVE
The objective of the study was to assess whether folic acid intake during the first trimester of pregnancy is related to asthma in the offspring by the age of 6 years.
STUDY DESIGN
This was a prospective cohort study of 1499 women who were followed up from the first trimester of pregnancy. Their children were followed up until they were 6 years old.
RESULTS
Fifty-one percent of the women used folic acid in the month before conception and 88% in the third month of pregnancy. The adjusted odds ratio for asthma per 100 μm increase in the average daily intake of folic acid was 0.98 (95% confidence interval, 0.93-1.04). For categories of daily folate intake, there was no evidence of associations with childhood asthma or evidence of any dose response relation for any time period (all P(trend) > .05).
CONCLUSION
Our results do not support any association of folic acid supplementation in pregnancy and asthma risk in offspring by age 6 years.
摘要
目的
本研究旨在评估孕妇妊娠早期叶酸摄入量与 6 岁以下儿童哮喘之间的关系。
研究设计
这是一项前瞻性队列研究，共纳入了 1499 名女性，随访时间从妊娠早期开始。对她们的孩子进行随访，直到他们 6 岁为止。
结果
51%的女性在受孕前 1 个月使用叶酸，88%的女性在妊娠第 3 个月使用叶酸。平均每日叶酸摄入量每增加 100 μm，哮喘的调整优势比为 0.98（95%置信区间，0.93-1.04）。对于每日叶酸摄入量的类别，没有证据表明与儿童哮喘有关，也没有证据表明任何时间区间存在剂量反应关系（所有 P（趋势）>.05）。
结论
我们的研究结果不支持妊娠期间补充叶酸与 6 岁以下儿童哮喘风险之间存在关联。
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