在实施强制食品强化项目的国家中，服用叶酸补充剂的女性可能已超过叶酸可耐受最高摄入量：系统评价。

Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review.

机构信息

School of Public Health, University of Technology, P.O. Box 123, Sydney, NSW 2007, Australia.

School of Nursing and Midwifery, Faculty of Health, University of Technology, P.O. Box 123, Sydney, NSW 2007, Australia.

出版信息

Nutrients. 2022 Jun 29;14(13):2715. doi: 10.3390/nu14132715.

BACKGROUND

In preconception and pregnancy, women are encouraged to take folic acid-based supplements over and above food intake. The upper tolerable limit of folic acid is 1000 mcg per day; however, this level was determined to avoid masking a vitamin B12 deficiency and not based on folic acid bioavailability and metabolism. This review's aim is to assess the total all-source intake of folate in women of childbearing age and in pregnancy in high-income countries with folate food fortification programs.

METHODS

A systematic search was conducted in five databases to find studies published since 1998 that reported folate and folic acid intake in countries with a mandatory fortification policy.

RESULTS

Women of childbearing age do not receive sufficient folate intake from food sources alone even when consuming fortified food products; however, almost all women taking a folic acid-based supplement exceed the upper tolerable limit of folic acid intake.

CONCLUSIONS

Folic acid supplement recommendations and the upper tolerable limit of 1000 mcg set by policy makers warrant careful review in light of potential adverse effects of exceeding the upper tolerable limit on folic acid absorption and metabolism, and subsequent impacts on women's health during their childbearing years.

背景

在受孕前和妊娠期间，鼓励女性在摄入食物之外额外补充叶酸类补充剂。叶酸的可耐受最高摄入量为每天 1000 微克；然而，这一水平是为了避免掩盖维生素 B12 缺乏症而确定的，而不是基于叶酸的生物利用度和代谢。本综述的目的是评估在实施叶酸食物强化计划的高收入国家中，育龄妇女和妊娠期的总叶酸全部来源摄入量。