Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.
Am J Ophthalmol. 2012 Feb;153(2):284-290.e1. doi: 10.1016/j.ajo.2011.06.027. Epub 2011 Oct 6.
To investigate the corneal higher-order aberrations (HOAs) of the anterior and posterior corneal surfaces in eyes that underwent penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), and Descemet stripping automated endothelial keratoplasty (DSAEK).
Retrospective, case-control study.
study population: Twenty-four eyes underwent PK, 28 eyes underwent DALK, and 19 eyes underwent DSAEK; 29 normal eyes served as controls. observation procedures: The anterior and posterior corneal heights and pachymetric data were obtained with a Scheimpflug-based corneal topographer. Corneal HOAs for 4-mm pupils were calculated from the height data and were expanded with normalized Zernike polynomials. The HOAs resulting from the anterior and posterior corneal surfaces were compared among the procedures. main outcome measures: Anterior and posterior corneal HOAs (root mean square).
Control eyes had significantly lower total HOAs and Zernike vector terms of the anterior and posterior surfaces than the other groups, except for spherical aberration. The mean anterior corneal surface total HOAs in the PK, DALK, DSAEK, and control groups were 1.38 ± 0.67 μm, 1.19 ± 0.57 μm, 0.61 ± 0.33 μm, and 0.21 ± 0.07 μm, respectively. The anterior corneal HOAs in the DSAEK group were significantly less than those in the PK group (P < .001) and DALK group (P < .001). The mean posterior corneal surface total HOAs were, respectively, 0.20 ± 0.09 μm, 0.24 ± 0.11 μm, 0.27 ± 0.15 μm, and 0.07 ± 0.02 μm. There were no significant differences in the posterior corneal HOAs among the treatment groups.
Because the refractive indices between the anterior and the posterior surfaces differed greatly, eyes that undergo DSAEK have lower anterior corneal HOAs compared with PK or DALK eyes. However, the anterior and posterior corneal HOAs in DSAEK eyes still were greater than those in control eyes.
研究穿透性角膜移植术（PK）、深板层角膜移植术（DALK）和撕囊自动化角膜内皮移植术（DSAEK）后眼前、后表面角膜高阶像差（HOAs）。
回顾性病例对照研究。
研究人群：24 只眼行 PK，28 只眼行 DALK，19 只眼行 DSAEK；29 只正常眼作为对照。观察程序：使用基于 Scheimpflug 的角膜地形图仪获得前、后角膜高度和角膜厚度数据。从前部角膜高度数据计算 4mm 瞳孔的角膜 HOAs，并使用归一化 Zernike 多项式展开。比较不同手术方法的前、后角膜 HOAs。主要观察指标：前、后角膜 HOAs（均方根）。
对照组眼的总 HOAs 和前、后表面 Zernike 向量项明显低于其他组，除球差外。PK、DALK、DSAEK 和对照组的平均前角膜表面总 HOAs 分别为 1.38±0.67μm、1.19±0.57μm、0.61±0.33μm 和 0.21±0.07μm。DSAEK 组的前角膜 HOAs 明显小于 PK 组（P＜0.001）和 DALK 组（P＜0.001）。后角膜表面总 HOAs 分别为 0.20±0.09μm、0.24±0.11μm、0.27±0.15μm 和 0.07±0.02μm。各组间后角膜 HOAs 无显著差异。
由于前、后表面的折射率差异很大，因此与 PK 或 DALK 相比，行 DSAEK 的眼具有较低的前角膜 HOAs。然而，DSAEK 眼的前、后角膜 HOAs 仍大于对照组。
