Nigro M A, Castellani L, Chieregato C
Università degli Studi di Verona Clinica Dermatologica.
G Ital Dermatol Venereol. 1990 Mar;125(3):111-6.
Familial malignant melanoma with dysplastic (pleomorphic) nevus has been the most extensively investigated form of this neoplasm. Searches for dominant oncogenes and tumour recessive genes have been performed in various populations to clarify the pathogenesis of the disease. Some of the them have made in possible to localize the gene of the familial cutaneous melanoma with pleomorphic nevus on 1p chromosome. In various progression stages of this neoplasm different chromosomal abnormalities have been reported, which are only relatively specific of the disease stage. Growth substance (sex steroids, hormones, vitamins, immune factors, ions, prostaglandins, and others) regulate melanocyte proliferation and, perhaps, that of melanoma cells.
伴有发育异常（多形性）痣的家族性恶性黑色素瘤是该肿瘤研究最为广泛的一种形式。在不同人群中寻找显性癌基因和肿瘤隐性基因，以阐明该疾病的发病机制。其中一些研究已使得将伴有多形性痣的家族性皮肤黑色素瘤基因定位到1号染色体成为可能。在该肿瘤的不同进展阶段，已报道了不同的染色体异常情况，这些异常仅相对特定于疾病阶段。生长物质（性激素、激素、维生素、免疫因子、离子、前列腺素等）调节黑素细胞的增殖，或许也调节黑色素瘤细胞的增殖。
