Nigro M A, Castellani L, Chieregato C
Università degli Studi di Verona Clinica Dermatologica.
G Ital Dermatol Venereol. 1990 Mar;125(3):105-9.
Melanoma incidence is rapidly increasing in several countries. This neoplasm has been consistently studied in patients with dysplastic (pleomorphic) nevus, mainly in Anglo-Saxon populations. There is no evidence that among Italians the sequence pleomorphic nervus----cutaneous malignant melanoma shares the identical pathophysiologic mechanisms with the above mentioned form. Pleomorphic nevi are generally thought to be precursors of malignant melanoma of the skin, due to their chromosomal instability. Also common acquired nevi are lesions which can exhibit, although exceptionally, chromosomal abnormalities. Consequently, the sequence pleomorphic nevus----cutaneous malignant melanoma could also include the common nevus. The clinical implications of this stand-point, however, are to be more extensively investigated.
黑色素瘤发病率在一些国家正迅速上升。这种肿瘤一直在发育异常（多形性）痣患者中进行持续研究，主要是在盎格鲁 - 撒克逊人群中。没有证据表明在意大利人中，多形性痣——皮肤恶性黑色素瘤序列与上述形式具有相同的病理生理机制。多形性痣通常被认为是皮肤恶性黑色素瘤的前体，因为它们具有染色体不稳定性。同样，常见的后天性痣虽然极为罕见，但也可能表现出染色体异常。因此，多形性痣——皮肤恶性黑色素瘤序列可能也包括普通痣。然而，这一观点的临床意义还有待更广泛地研究。
