Université Catholique de Louvain, Cliniques Universitaires St. Luc, Department of Gynecology, Brussels, Belgium.
Fertil Steril. 2011 Dec;96(6):1407-11. doi: 10.1016/j.fertnstert.2011.09.012. Epub 2011 Oct 6.
To report the restoration of ovarian function in a woman with Turner syndrome by allografting ovarian cortex from her monozygotic twin.
Case report.
Gynecology research unit in a university hospital.
PATIENT(S): A 37-year-old woman with Turner syndrome who had suffered premature ovarian failure (POF) at the age of 15.
INTERVENTION(S): In this woman, we performed ovarian cortex transplantation. The donor was her monozygotic twin who had not experienced POF and who had had two normal deliveries.
MAIN OUTCOME MEASURE(S): Restoration of ovarian activity and pregnancy.
RESULT(S): Restoration of ovarian function was achieved 3 months after transplantation. After 7 months of regular cycles, spontaneous pregnancy occurred. The patient delivered a healthy baby girl weighing 2,850 g at 38 weeks of gestation.
CONCLUSION(S): Girls with Turner syndrome suffer accelerated loss of ovarian follicles and only 2%-5% experience spontaneous menses with the potential to achieve pregnancy without medical intervention. This manuscript reports the first live birth after allografting between monozygotic twins with 45,XO/46,XX mosaicism and discordant growth pattern and ovarian function.
报告一例通过同卵双胞胎供体卵巢皮质同种异体移植恢复特纳综合征妇女卵巢功能的病例。
病例报告。
一所大学医院的妇科研究单位。
一名 37 岁的特纳综合征妇女，15 岁时发生卵巢早衰（POF）。
对该妇女进行了卵巢皮质移植。供体是她未经历 POF 且已生育两次的同卵双胞胎。
卵巢活动和妊娠的恢复情况。
移植后 3 个月恢复卵巢功能。经过 7 个月的正常周期，自然妊娠发生。患者在 38 周妊娠时分娩了一名 2850 克重的健康女婴。
特纳综合征女孩的卵巢卵泡加速丢失，只有 2%-5%的患者在未经医学干预的情况下出现自发性月经并有怀孕的潜力。本研究报告了首例具有 45，XO/46，XX 嵌合体和不一致生长模式及卵巢功能的同卵双胞胎之间同种异体移植后活产的病例。
