Insect Infection and Immunity Lab, Department of Biological Sciences, The George Washington University, 336 Lisner Hall, 2023 G Street NW, Washington, DC 20052, USA.
Trends Parasitol. 2011 Dec;27(12):537-47. doi: 10.1016/j.pt.2011.09.001. Epub 2011 Oct 6.
Host innate immunity plays a central role in detecting and eliminating microbial pathogenic infections in both vertebrate and invertebrate animals. Entomopathogenic or insect pathogenic nematodes are of particular importance for the control of insect pests and vectors of pathogens, while insect-borne nematodes cause serious diseases in humans. Recent work has begun to use the power of insect models to investigate host-nematode interactions and uncover host antiparasitic immune reactions. This review describes recent findings on innate immune evasion strategies of parasitic nematodes and host cellular and humoral responses to the infection. Such information can be used to model diseases caused by human parasitic nematodes and provide clues indicating directions for research into the interplay between vector insects and their invading tropical parasites.
宿主先天免疫在脊椎动物和无脊椎动物中检测和消除微生物致病性感染方面发挥着核心作用。昆虫病原或昆虫致病性线虫对于控制害虫和病原体的媒介尤为重要，而虫媒线虫会导致人类患上严重疾病。最近的研究开始利用昆虫模型的力量来研究宿主-线虫相互作用，并揭示宿主抗寄生虫免疫反应。本综述描述了寄生线虫逃避先天免疫的策略以及宿主对感染的细胞和体液反应的最新发现。这些信息可用于模拟由人类寄生线虫引起的疾病，并提供线索，表明方向，以研究媒介昆虫与其入侵的热带寄生虫之间的相互作用。
