Huynh Tien, O'Halloran Damien, Hawdon John, Eleftherianos Ioannis
Department of Biological Sciences, The George Washington University, Washington, DC, USA.
Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, DC, USA.
MicroPubl Biol. 2023 Sep 25;2023. doi: 10.17912/micropub.biology.000944. eCollection 2023.
Entomopathogenic nematodes are commonly used to control insect pest populations in the field. They also contribute substantially to understanding the molecular basis of nematode pathogenicity and insect anti-nematode immunity. Here, we tested the effect of the entomopathogenic nematode on the survival and immune signaling regulation of wild type larvae. Our results indicate that infective juveniles are pathogenic toward larvae, but they fail to activate certain immune pathway readout genes. These findings imply that employs mechanisms that allow these parasitic nematodes to interfere with the immune system.
昆虫病原线虫通常用于控制田间害虫种群。它们对于理解线虫致病性和昆虫抗线虫免疫的分子基础也有很大贡献。在此，我们测试了昆虫病原线虫对野生型幼虫存活和免疫信号调节的影响。我们的结果表明，感染性幼虫对幼虫具有致病性，但它们无法激活某些免疫途径读数基因。这些发现意味着采用了使这些寄生线虫能够干扰免疫系统的机制。
