Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway.
Prev Vet Med. 2012 Feb 1;103(2-3):219-27. doi: 10.1016/j.prevetmed.2011.09.018. Epub 2011 Oct 6.
We conducted a prospective cohort study including privately owned dogs from the breeds Newfondland (NF), Labrador Retriever (LR), Leonberger (LEO), and Irish Wolfhound (IW) followed from birth until age 9 yrs. We wanted to investigate whether radiological hip dysplasia status given at approximately age 12-18 mos and other factors during growth influenced development of clinical signs due to hip-joint disease necessitating veterinary consultation. Whether or not such signs occurred due to hip dysplasia or due to secondary or primary DJD could not be distinguished, and we therefore used the term "owner-reported veterinary-diagnosed hip-related clinical signs" ("the event"). The included dogs were followed from birth to the event or until a maximum of 9 yrs of age. Our objectives were to describe breed differences in time to incidence and to evaluate potential risk factors for the time to event. We used Kaplan-Meier curves to describe time to incidence, and potential risk factors were assessed by use of a Cox proportional-hazards model. We enrolled 494 dogs from 103 litters, and 46 dogs were reported as having had the event during the observation period. We observed a significant time-varying effect (TVE): LR and LEO developed clinical signs later in life than NF. If the radiological hip status was either mild, moderate, or severe the hazard of experiencing the event was significantly increased. Access to off-leash exercise at age 12 mos decreased the hazard of the event, and the hazard varied by litter. The findings supported the hypothesis that radiological hip status at screening and exercise conditions during growth influenced the time to incidence of the event and that there were breed differences in time to the event.
我们进行了一项前瞻性队列研究，纳入了从纽芬兰犬（NF）、拉布拉多猎犬（LR）、莱昂贝格尔犬（LEO）和爱尔兰猎狼犬（IW）等私人拥有的犬种中选取的犬只，从出生开始一直随访至 9 岁。我们希望研究在大约 12-18 月龄时进行的放射学髋关节发育不良评估以及生长过程中的其他因素是否会影响髋关节疾病导致的临床症状的发展，这些症状需要兽医咨询。我们无法区分这些临床症状是由髋关节发育不良引起的，还是由继发性或原发性 DJD 引起的，因此我们使用了“主人报告的兽医诊断的髋关节相关临床症状”（“该事件”）这一术语。纳入的犬只从出生开始随访至该事件发生或最长 9 岁。我们的目标是描述不同品种犬髋关节发育不良的时间，并评估时间到事件的潜在危险因素。我们使用 Kaplan-Meier 曲线描述时间到发病率，并使用 Cox 比例风险模型评估潜在的危险因素。我们共纳入了 103 窝 494 只犬，其中 46 只犬在观察期间报告发生了该事件。我们观察到一个显著的时间变化效应（TVE）：LR 和 LEO 比 NF 更晚出现临床症状。如果放射学髋关节状态为轻度、中度或重度，那么经历该事件的风险显著增加。12 月龄时的无绳运动机会降低了该事件的风险，且风险因窝而异。这些发现支持了以下假设：筛选时的放射学髋关节状态和生长过程中的运动条件会影响事件发生的时间，并且不同品种犬髋关节发育不良的时间存在差异。
