Talebi Mahnaz, Savadi-Oskouei Dariush, Farhoudi Mehdi, Mohammadzade Solmaz, Ghaemmaghamihezaveh Seyyedjamal, Hasani Akbar, Hamdi Amir
Department of Neurology, Tabriz University of Medical Sciences, Tabriz, Iran.
Neurosciences (Riyadh). 2011 Oct;16(4):320-3.
The determination of serum magnesium levels in migraine.
In a case control study performed between January 2007 and December 2007 at Tabriz University of Medical Sciences, Tabriz, Iran, 140 migraine patients were enrolled and their level of serum magnesium was determined and the results were compared with 140 healthy people who did not have any headache, kidney, or gastrointestinal disorders, and no consumption of magnesium complements.
Migraine patients (22 male, 118 female) with a mean age of 33.82+/-10.31 and 140 healthy people (26 male, 114 female) with a mean age of (34.19+/-9.95) were enrolled. Forty patients had aura and 100 patients did not have aura. The average serum magnesium level in the patient group (26.14+/-4.3) was significantly lower than the control (31.09+/-4.32) group (p=0.000). There was no significant difference between the mean level of serum magnesium in patients with migraine with aura and without aura, however, there was a significant linear relationship between the amount of serum magnesium and the frequency of headache.
Serum magnesium in migraine patients was significantly lower than the normal population and related to the frequency of migraine attacks, supporting the use of magnesium in prevention and treatment of migraine.
测定偏头痛患者的血清镁水平。
于2007年1月至2007年12月在伊朗大不里士医科大学进行了一项病例对照研究，纳入140例偏头痛患者，测定其血清镁水平，并将结果与140名无头痛、肾脏或胃肠道疾病且未服用镁补充剂的健康人进行比较。
纳入偏头痛患者（男22例，女118例），平均年龄33.82±10.31岁，以及140名健康人（男26例，女114例），平均年龄（34.19±9.95）岁。40例患者有先兆，100例患者无先兆。患者组的平均血清镁水平（26.14±4.3）显著低于对照组（31.09±4.32）（p = 0.000）。有先兆偏头痛患者与无先兆偏头痛患者的血清镁平均水平之间无显著差异，然而，血清镁含量与头痛频率之间存在显著的线性关系。
偏头痛患者的血清镁水平显著低于正常人群，且与偏头痛发作频率相关，支持使用镁来预防和治疗偏头痛。
