Kumar Agrawal Adesh, Das Soumitra, Abednego B Adre Lorenzo, Raghuma Nakka, Kaushik Sharanya, Adhikari Adarsha
All India Institute of Medical Sciences, Deoghar, India.
Department of Psychiatry, Western Health, Victoria, Australia.
Case Rep Psychiatry. 2024 Feb 20;2024:9147674. doi: 10.1155/2024/9147674. eCollection 2024.
Clozapine is an antipsychotic medicine used to treat mental illnesses that is resistant to therapy. It can induce dose-dependent adverse effects such as increased susceptibility to infections and hematological irregularities. In this case report, we present a 37-year-old woman with schizoaffective disorder who experienced clozapine side effects following a moderate urinary tract infection (UTI). Her serum clozapine levels and side effects were increased throughout her UTI but resolved once the UTI was managed conservatively. We reviewed clozapine's pharmacokinetic properties to understand why serum levels rose during infection. While we could not definitely explain the mechanism of elevation, we emphasize the importance of monitoring serum clozapine levels and keeping watchful for adverse effects, as well as heightened scrutiny, evaluation for recent infections, and regular monitoring of patients.
氯氮平是一种用于治疗难治性精神疾病的抗精神病药物。它可引发剂量依赖性不良反应，如感染易感性增加和血液学异常。在本病例报告中，我们介绍了一名37岁患有精神分裂症的女性，她在中度尿路感染（UTI）后出现了氯氮平副作用。在整个尿路感染期间，她的血清氯氮平水平和副作用均有所增加，但在尿路感染保守治疗后恢复正常。我们回顾了氯氮平的药代动力学特性，以了解感染期间血清水平升高的原因。虽然我们无法确切解释升高的机制，但我们强调监测血清氯氮平水平、密切关注不良反应的重要性，以及加强对近期感染的审查、评估和对患者的定期监测。
