McMahon Stephen, Hawdon Gabrielle, Baré John, Yu Yan, Bertollo Nicky, Walsh William R
Malabar Orthopaedic Institute, and Monash University, Melbourne, Australia.
Hip Int. 2011 Sep-Oct;21(5):616-22. doi: 10.5301/HIP.2011.8704.
The use of PMMA cement is common in arthroplasty for cemented fixation and defect filling. Concerns remain regarding effects of cement curing temperature on the viability of cancellous bone. In this study we filled surgically-created defects (mean volume 0.585±0.251 mL) in the cancellous bone of the distal femur and proximal tibia of 6 sheep with PMMA and measured temperature changes in surrounding bone whilst the cement cured, using 3 thermocouples per defect. Animals were euthanised at 3 (n=3) and 12 (n=3) weeks postoperatively and the bone-cement interface assessed histologically. Despite mean maximum temperatures of 49.3±10.2 °C (range: 40.9 °C - 82.2 °C) thermonecrosis was not a common histological feature at either timepoint. The exposure of bone to high cement temperatures in this study has not led to bone necrosis and/or tissue damage.
聚甲基丙烯酸甲酯（PMMA）骨水泥在关节置换术中用于骨水泥固定和骨缺损填充十分常见。骨水泥固化温度对松质骨活力的影响仍受关注。在本研究中，我们用PMMA填充了6只绵羊股骨远端和胫骨近端松质骨中手术制造的缺损（平均体积0.585±0.251 mL），每个缺损使用3个热电偶测量骨水泥固化时周围骨的温度变化。术后3周（n = 3）和12周（n = 3）对动物实施安乐死，并对骨水泥界面进行组织学评估。尽管平均最高温度为49.3±10.2℃（范围：40.9℃ - 82.2℃），但在两个时间点热坏死均不是常见的组织学特征。本研究中骨暴露于高骨水泥温度并未导致骨坏死和/或组织损伤。
