绵毛马先蒿及其相关化合物的抗 HCV 和抗菌活性。
Compounds from Arnebia euchroma and their related anti-HCV and antibacterial activities.
机构信息
The College of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
出版信息
Planta Med. 2012 Jan;78(1):39-45. doi: 10.1055/s-0031-1280266. Epub 2011 Oct 7.
Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and compounds 1, 6, and des-O-methyllasiodiplodin (7) showed anti-Staphylococcus aureus activity with MICs of 0.5, 0.125, and 0.125 mg/mL, respectively.
从 ARNEBIA EUCHROMA 的茎皮中分离得到三种新的具有苯并庚菲骨架的对苯二酚三萜类化合物，即 euchroquinols A-C（1-3），以及一个新的单萜基苯并酚化合物 9,17-环氧阿内宾醇（4），同时还分离得到了五种已知化合物。紫草素（6）表现出很强的抗 HCV 活性，选择性指数为 43.56，化合物 1、6 和去甲-拉西多甙（7）对金黄色葡萄球菌的 MIC 分别为 0.5、0.125 和 0.125mg/mL。
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