Singh Lokesh Kumar, Maheshwari Dinesh Kumar, Shukla Shruti
a Department of Botany and Microbiology , Gurukul Kangri University , Haridwar 249-404 , Uttrakhand , India.
b Department of Food Science and Technology , Yeungnam University , Gyeongsan, Gyeongbuk 712-749 , Republic of Korea.
Nat Prod Res. 2015;29(24):2299-301. doi: 10.1080/14786419.2015.1004676. Epub 2015 Jan 30.
This study was carried out to investigate the biomedicinal potential of a bioactive marker component, butyryl alkannin, isolated from n-hexane root extract of Arnebia euchroma against various vancomycin-resistant Enterococcus (VRE) isolates of Enterococcus faecalis causing urinary tract infections. As a result, butyryl alkannin showed significant antibacterial activity against multidrug-resistant E. faecalis pathogens of VRE as minimum inhibitory concentration values which were found in the range of 3.13 to 6.26 μg ml(-1). The findings of this study justify biological and biomedicinal potential of butyryl alkannin compound as confirmed by its higher and significant antibacterial efficacy against VRE isolates of E. faecalis as compared to standard antibiotic vancomycin.
本研究旨在探究从新疆紫草正己烷根提取物中分离出的一种生物活性标记成分——丁酰紫草素，对引起尿路感染的粪肠球菌的各种耐万古霉素肠球菌（VRE）分离株的生物医学潜力。结果表明，丁酰紫草素对VRE的多重耐药粪肠球菌病原体具有显著的抗菌活性，其最低抑菌浓度值在3.13至6.26μg/ml范围内。本研究结果证明了丁酰紫草素化合物的生物学和生物医学潜力，与标准抗生素万古霉素相比，它对粪肠球菌的VRE分离株具有更高且显著的抗菌效果。
