Shoklo Malaria Research Unit, Mae Sot 63110, Thailand.
J Trop Pediatr. 2012 Aug;58(4):311-3. doi: 10.1093/tropej/fmr088. Epub 2011 Oct 7.
Prompt antibiotic treatment for infants with sepsis has the potential to save lives. A rectal formulation of an antibiotic could be used at a village level before referral to hospital. The development of such a preparation needs to take into account the rectal pH of infants that will affect drug partitioning and absorption. Rectal pH measurements were taken in 100 well and 45 unwell infants. We also measured rectal pH in 14 infants sequentially over the course of their illness. The mean rectal pH was 6.75 with no significant difference in well or unwell infants. The mean (95% CI) rectal pH of well neonates was significantly lower than that of older infants (>28 days): 6.47 (6.29-6.65) vs. 6.90 (6.68 to 7.12) p = 0.003.
对患有败血症的婴儿进行抗生素治疗有潜在的挽救生命的作用。一种抗生素的直肠制剂可在转诊到医院之前在村级使用。这种制剂的开发需要考虑到会影响药物分配和吸收的婴儿的直肠 pH 值。对 100 名健康婴儿和 45 名患病婴儿进行了直肠 pH 值测量。我们还对 14 名婴儿在患病过程中的直肠 pH 值进行了连续测量。直肠 pH 值的平均值为 6.75，健康和患病婴儿之间没有显著差异。健康新生儿的直肠 pH 值平均值（95%CI）明显低于年龄较大的婴儿（>28 天）：6.47（6.29-6.65）vs. 6.90（6.68 至 7.12）p=0.003。
