Jantzen J P, Tzanova I, Witton P K, Klein A M
Department of Anaesthesiology, Johannes Gutenberg, University Medical School, Mainz, F.R.G.
Can J Anaesth. 1989 Nov;36(6):665-7. doi: 10.1007/BF03005418.
In an attempt to establish normal values for rectal pH in children, we have measured pH in 100 paediatric patients. Measurement of rectal pH was performed in 25 infants and 75 children (27 girls and 73 boys) using a monocrystalline antimony electrode. Rectal pH was 9.6 +/- 0.9 (mean +/- SD, range 7.2 to 12.1) and was independent of sex, age and nutrition. This wide range of rectal pH values offers a possible explanation for the widely scattered bioavailability of drugs administered by the rectal route. Mean rectal pH was considerably higher than that reported for adults; this unexpected alkalinity should be taken into account, when drug formulations are considered for rectal administration in children.
为了确定儿童直肠pH值的正常范围，我们对100例儿科患者进行了pH值测量。使用单晶锑电极对25名婴儿和75名儿童（27名女孩和73名男孩）进行直肠pH值测量。直肠pH值为9.6±0.9（平均值±标准差，范围7.2至12.1），且与性别、年龄和营养状况无关。直肠pH值的这种广泛范围为经直肠途径给药的药物生物利用度广泛分散提供了一种可能的解释。平均直肠pH值明显高于成人报告的值；在考虑儿童直肠给药的药物制剂时，应考虑到这种意外的碱性。
